KP01 - The Biomedical Century and its Opportunities for Drug Development
Guenter Stock,
Schering AG
Presenting Author: Guenter Stock, Schering AG - Germany

KP02 - NMR for Screening and Structure Determination in Structural Genomics
Kurt Wüthrich,
Scripps Reasearch Institute, USA & Institute of Molecular Biology and Biophysics, Switzerland
Presenting Author: Kurt Wüthrich, Scripps Reasearch Institute - USA

1A01 - Pharmacogenomics at the Bedside
Jeffrey S. Ross,
Albany Medical College MC-80
Presenting Author: Jeffrey Ross, Albany Medical College MC-80 - USA
Plenary Speaker

1A02 - Use Of Flow Cytometry For Biomarker Analysis in Pre-clinical and Clinical Phases of New Drug Development
Philip Marder, Lisa Green, Rita Bowers and Haiyan Long,
Lilly Research Laboratories
Presenting Author: Philip Marder, Lilly Research Labs - USA

1A03 - DNA Methylation-Based Outcome Prediction in Breast Cancer
Nadia Harbeck,
Technische Universität München
Presenting Author: Dr. med. Nadia Harbeck , Technische Universität München - Germany

1B01 - Genome-Wide Drug Target Discovery with siRNA Libraries and Pathway-Specific Reporter Vectors
Alex Chenchik,
SBI
Presenting Author: Alex Chenchik, SBI - USA

1B02 - Gene Screening on a Genomic Scale with Oligonucleotides.
Jonathan Hall, Dieter Huesken, Mark Labow, Joerg Lange, Craig Mickanin, Francois Natt,
Novartis Institutes of BioMedical Research
Presenting Author: JONATHAN HALL, Novartis Institutes of BioMedical Research - Switzerland

1B03 - High-Content Screening Using Human Kinase and Phosphatase siRNA Libraries: Screening Design and Applications.
Eberhard Krausz,
Max Planck Institute of CBG
Presenting Author: Eberhard Krausz, Max Planck Institute of CBG - Germany

1B04 - Comprehensive Gene Expression Profiling of GPCRs and Ion Channels
Andrea Brambilla, Francesca Zolezzi, Paolo Guarnieri, Chiara Villa, Claudio Gattuso and Paola Tarroni,
Axxam
Presenting Author: Paola Tarroni, Axxam - Italy

1C01 - Recent Trends in Library Design: 'Rational Design' Revisited
Dora Schnur, Stanley Krystek,
Bristol-Myers Squibb
Presenting Author: Dora Schnur, Bristol-Myers Squibb - USA
Plenary Speaker

1C02 - Discovery of Novel Nonpolar Interactions Between Influenza Neuraminidase and Oseltamivir and Its Implication on Virtual Screening
Xiaowu Chen, James M. Chen, and S. Swaminathan,
Gilead Sciences
Presenting Author: Xiaowu Chen, Gilead Sciences - USA

1C03 - The ZINC Database for vHTS and Focused Libraries
John J. Irwin and Brian K. Shoichet,
University of California, San Francisco
Presenting Author: John Irwin, University of California, San Francisco - USA

2A01 - Organizing Chemical Information by Molecular Shape and Electrostatics
Anthony Nicholls,
OpenEye Scientific Software, Inc.
Presenting Author: Anthony Nicholls, OpenEye Scientific Software - USA
Plenary Speaker

2A02 - Statistically-guided Selection of Primary Positives in HTS
Julio Martin and Jesus Herranz,
GlaxoSmithKline
Presenting Author: Julio Martin, GlaxoSmithKline - Spain

2A03 - Ring-system Based Fragments for the Analysis of Structure-Activity Relationships
Ramaswamy Nilakantan, David Nunn, Kevin Haraki, Gary Walker, Lynne Greenblatt and Dominick Mobilio,
Wyeth Research
Presenting Author: Ramaswamy Nilakantan, Wyeth Research - USA

2A04 - An Efficient Method for Lead Identification using Iterative Focused Screening
Christine Brideau, Christopher Bayly, Andy Liaw and Vladimir Svetnik,
Merck Frosst Center for Therapeutic Research and Merck Research Laboratories
Presenting Author: Christine Brideau, Merck Frosst Canada & Co. - Canada

2B01 - Evaluation of Different HTS Strategies: Pool10 vs. Single Compound Screening
Ulf Bömer, Drew Sukovich (Berlex Biosciences), Benjamin Bader, Christian Bergsdorf, Manfred Husemann, Gernot Langer, Janet Meurer (Berlex Biosciences), Sofia Ribeiro (Berlex Biosciences), Karsten Parczyk, Michael Snider (Berlex Biosciences),
Schering AG
Presenting Author: Ulf Bömer, Schering AG - Germany

2B02 - Technologies Implemented at Berlex for Screening GPCRs Over the Past 10 Years
Sofia Ribeiro, April Holbrook, Paymann Harirchian, Steve Jones, Lan Trinh, Laura Dunning, Lorraine Kent, Meina Liang, Mary Rosser, Kieu Chu and Michael Snider,
Berlex Biosciences
Presenting Author: Sofia Ribeiro, Berlex Biosciences - USA

2B03 - From Manual Screening to Full Automation and Back: Comparing HTS Approaches with a Focus on Resource and Time
Joe Bradley, Philip Gribbon, Andreas Sewing, Wilma Keighley,
Pfizer Ltd.
Presenting Author: Joe Bradley, Pfizer Ltd - UK

2B04 - Novartis NanoScreening - Merging Single Molecule Detection and 'Classical' Assay Technologies in One HTS Platform Efficiently
Johannes Ottl,
Novartis Institute for BioMedical Research
Presenting Author: Johannes Ottl, Novartis - Switzerland

2B05 - Evaluation of cAMP Detection Technologies for Screening G_s and G_i Coupled Receptors
Maite de los Frailes, Francisco Colilla, Emilio Alvarez, Julio Martín, Liz Clark, Rob Slack, Nicola Bevan, Amanda Emmons, Ryan Bingham and James P Villa,
GSK
Presenting Author: Maite de los Frailes, GSK - Spain

2C01 - Single-well Gene Silencing on Multiple Cell Lines: Identification
Oren Beske, Daniel Bassoni, And Simon Goldbard,
Vitra Bioscience Inc.
Presenting Author: Simon Goldbard, Vitra Bioscience - USA

2C02 - Electrogenic Proteins: from Cell Based Assays Generation to High Throughput Screening Application
Sabrina Corazza, Michela Stucchi, Elisa Redaelli, Alessandro Taddei and Stefan Lohmer,
Axxam,srl
Presenting Author: Sabrina Corazza, Axxam - Italy

2C03 - Automated and Rapid Multigene Stable Cell Line Production
Kambiz Shekdar, Dennis Sawchuk Jessica Langer and Gunter Blobel (Rockefeller University),
Chromocell Corporation
Presenting Author: Kambiz Shekdar, Chromocell Corporation - USA

2C04 - Optimizing Protein Stability and Function - Impact of ThermoFluor on Protein Overexpression and Primary Screening
James Kranz and Matthew Todd,
Johnson & Johnson Pharmaceutical Research and Development, L.L.C.
Presenting Author: James Kranz, Johnson & Johnson PRD - USA

2C05 - Use of Frozen Cells for Streamlining Functional Assays for GPCRs
Thierry Christophe, Béatrice Goxe, Emmanuelle Kaufmann, Emmanuel Burgeon and Jerome Bernard,
Euroscreen s.a.
Presenting Author: Jerome Bernard, EUROSCREEN - BELGIUM

3A01 - Calcium Channel Therapeutic Targets: Beyond the L-type
Terrance P. Snutch,
Neuromed Technologies Inc & University of British Columbia
Presenting Author: Terrance Snutch, Neuromed Technologies Inc & University of British Columbia - Canada
Plenary Speaker

3A02 - Population Patch Clamp Delivers Faster, Cheaper and Better Data
Alan Finkel, Jim Costantin, Andrew Wittel, Naibo Yang, Shawn Handran, Jan Hughes,
Molecular Devices Corporation
Presenting Author: Alan Finkel, Molecular Devices - USA

3A03 - Rapid Screening of Voltage-gated Sodium Channel (VGSC) Isoforms using Planar Array Electrophysiology
Tim Dale, Jenni Cryan and Derek Trezise,
GlaxoSmithKline R&D
Presenting Author: Tim Dale, GlaxoSmithKline - UK

3A04 - The Impact of Assay Technologies on Advancing Ion Channel Targets to Candidates.
Jennings Worley,
Vertex Pharmaceuticals
Presenting Author: Jennings Worley, Vertex Pharmaceuticals - USA

3B01 - Identification of Small Molecule Antagonists of the Human MRG-X1 Receptor
Priya Kunapuli, Seungtaek Lee, Wei Zheng, Melissa Alberts, Oleg Kornienko, Rebecca Mull and Berta Strulovici,
Merck & Co.
Presenting Author: Priya Kunapuli, Merck & Co. - U.S.A.

3B02 - Screening Compounds for Novel Mechanisms of GPCR Modulation
Duncan R. Groebe, Mary Maus, Jie Qian, Mario Mezler, Nelson Grihalde, Usha Warrior, and David Burns,
Abbott Laboratories
Presenting Author: Duncan Groebe, Abbott Laboratories - USA

3B03 - A Cell-Based Drug Screening Strategy For G Protein Coupled Receptors
Brian F. O'Dowd,
University of Toronto
Presenting Author: Brian O'Dowd, University of Toronto - Canada

3B04 - A New HTS Technology for GPCR Screening via ERK
Michael Crouch, Ronald Osmond and Anthony Dyer,
TGR BioSciences
Presenting Author: Michael Crouch, TGR BioSciences - Australia

3B05 - IP1 as a Surrogate of IP3 to Monitor G_q Coupled GPCR Response in a HTS Format
Eric Trinquet,
Cisbio international
Presenting Author: Eric Trinquet, Cisbio international - France

3C01 - Protease Directed Drug Discovery - A Platform Approach
Bernd Gerhartz, Ulrich Hassiepen, Nils Ostermann, Benoit Pierrat and Joerg Trappe,
Novartis Institutes for Biomedical Research
Presenting Author: Joreg Trappe, Novartis - Switzerland

3C02 - Kinase Screening Platform - The GSK Approach
Murray Brown,
GlaxoSmithKine Research and Development
Presenting Author: Murray Brown, GlaxoSmithKine Research and Development - UK

3C03 - Schering's Platform for Miniaturized Kinase Assays
Oliver von Ahsen, Dan Tran-Nguyen and Christian Bergsdorf,
Schering AG
Presenting Author: Oliver von Ahsen, Schering AG - Germany

3C04 - Choosing a Model Substrate for HTS
Leonard J. Blackwell, Dwayne Allen, Ioana Popa-Burke, Carla Suto, Nick Hodge, and Bill Janzen,
Amphora Discovery
Presenting Author: Leonard Blackwell, Amphora Discovery - United States

3C05 - Use of Flow-through Peptide Microarrays in Cell-lysate, Kinase and Inhibitor Screens
Rinie van Beuningen, Dirk D Pijnenburg, Diana D Melchers, Riet R Hilhorst, Piet P Boender, Adrienne A van de Berg and Rob R Ruijtenbeek,
PamGene International BV
Presenting Author: Rinie van Beuningen, PamGene International - The Netherlands

4A01 - In Vitro ADME Assays: The Good, the Bad and the Ugly
Charles L. Crespi,
BD Biosciences
Presenting Author: Charles Crespi, BD Biosciences - USA
Plenary Speaker

4A02 - High-Throughput Profiling Assays: How Useful for Decision Making?
Bernard Faller, Jacques Hamon, and Alfred Zimmerlin,
Novartis Institutes for BioMedical Research
Presenting Author: Bernard Faller, Novartis Institutes for BioMedical Research - Switzerland

4A03 - Drug Transporters in Developability and Predictive Toxicology Screening
Stephen Ashman, Andrew Ayrton, Namir Hassan, Danuta Mossakowska, Martin Rüdiger, Emma Watts, Kirsty Matthews, Alice Brown, Fernando Ramon, Glynis Nicholls, Sandeep Modi, Anne Hersey, Chris Luscombe, Stephen Pickett, Gavin Harper, Drake S. Eggleston and David Tew,
GlaxoSmithKline Pharmaceuticals Ltd.
Presenting Author: Stephen Ashman, GlaxoSmithKline Pharmaceuticals - UK

4A04 - Developing an Approach to Quantify Relationships Between Molecular Structure and Biological Effects to Reduce Drug Attrition
William Loging, Anton Fliri, Peter Thadeio, and Robert Volkmann,
Pfizer Inc.
Presenting Author: William Loging, Pfizer Inc. - USA

4B01 - An Image Informatics Pipeline for High Content Screening
Stephen Wong,
Harvard Medical School and Brighman & Women's Hospital
Presenting Author: Stephen Wong, Harvard Medical School - USA

4B02 - High-throughput Scanning with Single-molecule Sensitivity and Diffraction Limited Resolution
Max Sonnleitner, Guenter Freudenthaler, Dieter Hametner and Roland Pieler,
Upper Austrian Research GmbH
Jan Hesse and Gerhard Schuetz,
Johannes Kepler University Linz
Presenting Author: Max Sonnleitner, Upper Austrian Research - Austria

4B03 - Development and Implementation of a High Content Nuclear Receptor Nuclear Translocation Assay Panel to Drug Discovery
Taosheng Chen, Yingjie Zhu, Janet Kolb, Peg Prack, Rolf Ryseck, and Michele Agler,
Bristol-Myers Squibb
Presenting Author: Taosheng Chen, Bristol-Myers Squibb Comapny - USA

4B04 - Multi-Platform, Cytometric Imaging: a Picture is Worth a Thousand Data Points
Raffi Manoukian,
Amgen Inc.
Presenting Author: Raffi Manoukian, Amgen - USA

4B05 - Taking Full Advantage of High-content Screening Data for Automated Profiling of Drug Activity
Stephan Heyse, Martin Daffertshofer (Evotec Technologies GmbH), Annette Brodte, Oliver Duerr and Michael Lindemann,
Genedata AG
Presenting Author: Stephan Heyse, Genedata AG - Switzerland

4C01 - Programmable Microfluidics to Enable Benchtop Profiling and Selectivity Testing
Gianluca Lettieri, Helmut Mett, Walters Nyambi, Isabelle Semac, Bart Van de Vyver, Hervé Wioland, Piero Zucchelli,
SpinX Technologies
Presenting Author: Bart Van de Vyver, SpinX Technologies - Switzerland

4C02 - An Innovative Nanoprobe Technology for High-Throughput/High-Content Discovery of Drugs and Target Proteins in Living Human Cells
Jaejoon Won, Mina Kim, Yong-Weon Yi and Tae Kook Kim,
Korea Advanced Institute of Science and Technology
Presenting Author: Tae Kook Kim, Korea Advanced Institute of Science and Technology - South Korea

4C03 - Advancing Metabolomic Throughput and On-line Sample Fractionation with Automated Chip-based Nanoelectrospray Techniques
Christopher Tudan, Gary Schultz, Jack Henion and Stephen Lowes,
Advion BioSciences, Inc.
Presenting Author: Christopher Tudan, Advion BioSciences Inc. - USA

4C04 - Streamlining HTS for Group Transfer Enzymes
Karen Kleman-Leyer, Matt Staeben, Thane Westermeyer and Tony Klink, Robert Lowery,
BellBrook Labs
Presenting Author: Karen Kleman-Leyer, BellBrook Labs - USA

4C05 - Novel Disposable Devices for Precise Nanoliter Liquid Handling
Reinhard Steger, Wolfgang Streule, Roland Zengerle and Peter Koltay,
IMTEK-University of Freiburg
Presenting Author: Reinhard Steger, IMTEK-University of Freiburg - Germany

5A01 - Early Toxicology Screening for Hazard Identification in Lead Optimization
Claudia McGinnis, Xueying Cao, Maria Eckert and Joseph Gabriels,
Novartis Institutes for Biomedical Research
Presenting Author: Claudia McGinnis, Novartis - USA

5A02 - Genetic Toxicology: More To Learn from the Unknown?
Richard Walmsley, Nick Billinton, Andrew Knight and Paul Cahill,
Gentronix Ltd
Presenting Author: Richard Walmsley, Gentronix Ltd - UK

5A03 - Changes in the Dynamic Behavior of Cells as a Measure of Toxicity
Timo Ylikomi, T. Toimela, and H. Tähti,
University of Tampere
Presenting Author: Timo Ylikomi, University of Tampere - Finland

5B01 - Labeling Of Proteins In Living Cells - The SNAP-tag Technology
Andreas Brecht, Jan Barnikow, Maik Kindermann, Markus Schwab and Ron Tynes,
Covalys Biosciences AG
Presenting Author: Andreas Brecht, Covalys Biosciences AG - Switzerland

5B02 - Industrial Drug Discovery and Academic Research using a Forkhead Translocation Assay Cell Line
Søren Møller, David M. Sabatini (The Whitehead Institute for Biomedical Research), and Len Pagliaro,
BioImage A/S
Presenting Author: Len Pagliaro, BioImage A/S - Denmark

5B03 - Non-Invasive Assessment of Cell Growth, Confluence and Compound-induced Inhibition on Unlabelled Primary Human Cell Cultures
Kris Ver Donck, Peter Van Osta, Luc Bols, Marc Moeremans, Leen Geuens, Bieke Govaerts, and Johan Geysen,
MAIA SCIENTIFIC
Presenting Author: Kris Ver Donck, MAIA SCIENTIFIC - Belgium

5C01 - Label-Free Small Molecule Detection for High Throughput Screening
Lori Patnaude, Richard Nelson, Carol Ann Homon, Anthony Frutos (Corning Inc.) and Jeffrey Lynn (Corning Inc.)
Boehringer-Ingelheim Pharmaceuticals, Inc.
Presenting Author: Lori Patnaude, Boehringer Ingelheim Pharmaceuticals Inc. - USA

5C02 - Complex Signaling Pathway Analysis and Pharmacological Profiling via GPCRs using Cellular Dielectric Spectroscopy, A Novel Cellular Assay Technology
Ryan McGuinness, Gordon Leung, Uma Oza, H. Roger Tang, Vivian Liu, Julia Michelotti,
MDS Sciex
Presenting Author: Ryan McGuinness, MDS Sciex - USA

5C03 - Characterization of Cell Protein Translocation using Enzyme Fragment Complementation
Peter Fung, Kun Peng, Betty Bosano, Phil Kobel, Ganapathirama Raghu, Joe Horecka, Keith Olsen and Richard Eglen,
DiscoveRx Corp.
Presenting Author: Richard Eglen, DiscoveRx Corp - USA

KP03 - Biomarkers: Hype, Hope and the Reality of Health Care
Klaus Lindpaintner,
Roche Genetics & Roche Center for Medical Genomics
Presenting Author: Klaus Lindpaintner, Roche Genetics & Roche Center for Medical Genomics -

KP04 - The NIH Molecular Libraries Roadmap Initiative
Chris Austin,
NIH
Presenting Author: Chris Austin, NIH - USA