Presentation: KP04

The Molecular Libraries and Imaging Initiative (MLII) of the NIH Roadmap is an integrated set of programs which supports small molecule assay, screening, chemistry, and imaging technologies (http://nihroadmap.nih.gov/molecularlibraries). A centerpiece of the MLII is the Molecular Libraries Screening Center Network (MLSCN), a group of 10 screening centers that make high throughput biomolecular screening and focused chemistry optimization available to the research community. An MLSCN Small Molecule Repository supplies screening sets to the MLSCN centers, and all data from the MLSCN is made publicly available via PubChem (http://pubchem.ncbi.nlm.nih.gov). The products of the MLSCN are novel chemical probes of gene, cell, and biochemical pathway functions in health and disease. Technology development initiatives in chemical diversity, natural products chemistry, assays and assay platforms, HTS instrumentation, predictive ADMET, and cheminformatics complement and interact with the MLSCN, which provide testing grounds for the novel technologies developed. An analogous group of Molecular Imaging initiatives fund imaging probe production, database, and technology development programs.

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