| Gene Screening on a Genomic Scale with Oligonucleotides. |
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Presentation: 1B02 Session: From Genome to Therapeutic TargetsJonathan Hall, Dieter Huesken, Mark Labow, Joerg Lange, Craig Mickanin, Francois Natt, Novartis Institutes of BioMedical Research Presenting Author: JONATHAN HALL, Novartis Institutes of BioMedical Research - Switzerland One of the major challenges facing pharmaceutical research today is selection of the most important drug targets for any given disease indication. Gene screening on a genomic scale, using oligonucleotides, is quickly developing into a major source of novel molecular targets. The design, construction and application of a genomic set of siRNAs is described. An example of application of the set to link novel genes to a pathway is given. |