| High-throughput Scanning with Single-molecule Sensitivity and Diffraction Limited Resolution |
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Presentation: 4B02 Session: Imaging and High Content Screening: Valuable Tools Equally Embraced by Academia & Drug Screeners - Part 1Max Sonnleitner, Guenter Freudenthaler, Dieter Hametner and Roland Pieler, Upper Austrian Research GmbH Jan Hesse and Gerhard Schuetz, Johannes Kepler University Linz Presenting Author: Max Sonnleitner, Upper Austrian Research - Austria We present a fluorescence readout system for ultra-sensitive high-throughput scanning. The system is based on a technology that for the first time allows scanning of square centimeter areas with single molecule sensitivity and diffraction limited resolution within minutes. The novel detection technology can be applied to ultra-sensitive live cell screening, slide based cytometry, microarray readout and readout of bead-assays. The ultra-sensitivity will allow for revealing information not accessible with currently available detection strategies. |