P01001 - PIx: An Integrated Pharmacophore Informatics System for Analysis and Identification of Relations between Structures, Activities and Molecular Properties in High-Throughput Screening Data
Stefan M. Mundt, Roger M. Brunne, Andreas Göller, Michael W. Härter, Peter G. Nell and Joachim Mittendorf,
Bayer HealthCare AG,
William J. Scott, Jill E. Wood and Michael Brands,
Bayer HealthCare Co.
Presenting Author: Stefan Mundt, Bayer HealthCare AG - Germany

P01002 - Kinase Focused Library: Design, Validation and Application
Dongyu Sun, Claudio Chuaqui, Zhan Deng, Scott Bowes, Patrick Cullen and Serene Josiah,
Biogen Idec
Presenting Author: Dongyu Sun, BiogenIdec - USA

P01003 - A Specific Non-competitive Inhibitor of a Small G protein/GEF Complex
Alain Chavanieu, Julien Viaud, Mahel Zeghouf, Bernard Guibert, Catherine Royer, Jean-Francois Guichou, Jean-Christophe Zeeh, Jacqueline Cherfils,
Centre de Biochimie Structurale
Presenting Author: Alain Chavanieu, Centre de Biochimie Structurale - France

P01004 - Structure-Based Design, Synthesis, of Human Cyclophilin Inhibitors
Jean-Francois Guichou, Julien Viaud, Yea-Lih Lin, Dominique Douguet, Guy Subra, Clement Mettling and Alain Chavanieu,
Centre de Biochimie Structurale
Presenting Author: Jean-Francois Guichou, Centre de Biochimie Structurale - France

P01005 - Synergy of Advanced Virtual and High-throughput Screening Technologies for Increasing Productivity of Small Molecule Drug Discovery
Konstantin Balakin, Sergey Bugrov, Vasily Kazey, Yan Ivanenkov, Andrey Skorenko and Andrey Ivashchenko,
ChemDiv, Inc.
Presenting Author: Konstantin Balakin, ChemDiv, Inc. - USA

P01006 - Comprehensive Computational Assessment of ADME Properties Using Mapping Techniques
Konstantin Balakin, Yan A. Ivanenkov, Nikolay P. Savchuk, Andrey A. Ivashchenko and Sean Ekins (GeneGo, Inc.),
ChemDiv, Inc.
Presenting Author: Konstantin Balakin, ChemDiv, Inc. - USA

P01007 - Focused Library Sets in Discovery of Dual AT1/ETA Antagonists
Henrik Konarkowski and Alexander S. Kiselyov,
ChemDiv, Inc.
Presenting Author: Henrik Konarkowski, ChemDiv, Inc. - USA

P01008 - Novel BACE-1 Inhibitors for Alzheimer’s Disease Research. Selection of a Focused Library
Janos Gerencser, Cesare Spadoni, Gyorgy Dorman, Laszlo Urge, Ferenc Darvas, Zsolt Gulyas (ComGrid Ltd.), Sandor Cseh (RecomGenex Ltd.), Andrea Baki (Gedeon Richter Ltd.) and Gyorgy Keseru (Gedeon Richter Ltd.),
ComGenex, Inc.
Presenting Author: Janos Gerencser, ComGenex Inc. - Hungary

P01009 - Library Maintenance for the Smaller Pharma
Sally Hampton, Doreen Ashworth, Peter Robson, Chris Yea and James Barnett,
Ferring Research Ltd.
Presenting Author: Sally Hampton, Ferring Research Ltd - UK

P01010 - Simple Theoretical Criterion for Preselection of Compounds for HIV-chemotherapy
Nevena Veljkovic,
Institute of Nuclear Sciences VINCA
Presenting Author: Nevena Veljkovic, Institute for Nuclear Sciences VINCA - Serbia and Montenegro

P01011 - Selection of Docking Routine for Fast and Efficient Virtual Screening
Dmytro Koavslkyy, Maxim Platonov, Galina Dubinina, Volodymyr Dubina and Galina Dubinina,
Kiev National Taras Schevchenko University
Presenting Author: Dmytro Kovalskyy, Kiev National Taras Schevchenko University - Ukraine

P01012 - Cheminformatic Strategies for the Discovery of Inhibitors of the Enzyme MurG
Q. Kimberley Yue, Anthony E. Klon, Jeremy L. Jenkins, and Christian N. Parker,
Novartis Pharma AG,
Wen Wang, Peter Margolis, Dawn Chen and Zhengyu Yuan,
Vicuron Pharmaceuticals Inc
Presenting Author: Christian Parker, Novartis Pharma AG - Switzerland

P01013 - Valence Topological Charge-Transfer Indices for Dipole Moments: Percutaneous Enhancers
Francisco Torrens,
Universitat de Valencia
Presenting Author: Francisco Torrens, Universitat de Valencia - Spain

P01015 - New Methods for Statistical Analysis and Data Correction in HTS
Dmytro Kevorkov, Vladimir Makarenkov and Pablo Zentilli,
Universite du Quebec a Montreal
Presenting Author: Pablo Zentilli, University of Quebec in Montreal - Canada

P01016 - Improved Detection of Inhibitory Activity with Non-initial Rate Measurements
Omar A. Gutierrez and Helena Danielson,
Uppsala University
Presenting Author: Omar Gutierrez-Arenas, Uppsala University - Sweden

P01017 - Comparative Virtual and Experimental High-Throughput Screening for Glycogen Synthase Kinase-3β Inhibitors
Tímea Polgár, Andrea Baki, Györgyi I. Szendrei and György M. Keser,
Richetr Gedeon Ltd
Presenting Author: Timea Polgar, Richter Gedeon Ltd - Hungary

P02001 - Real-Time Monitoring of ROS and NO Generation and Apoptosis Kinetics in Individual, Non-Adherent Living Cells using the Optical LiveCell® Array
Naomi Zurgil and Motti Deutsch,
Bar-Ilan University / Molecular Cytomics Ltd.
Presenting Author: Naomi Zurgil, Bar Ilan University - Israel

P02002 - iHarness : Information Driven Image Informatics and Analysis Platform
Gauri Naik and Abhi Gholap,
Bioimagene Inc.
Presenting Author: Gauri Naik, Bioimagene Inc. - USA

P02003 - A High Content FRET Assay by Two-Color Anisotropy
Evan F. Cromwell, Madeleine L. Craske, Mark A. Rizzo (Vanderbilt University), David W. Piston (Vanderbilt University), Steven C. Miller,
Blueshift Biotechnologies, Inc.
Presenting Author: Evan Cromwell, Blueshift Biotechnologies - USA

P02004 - New Organotypic In-vitro Systems Emerge for Efficacy and Safety Testing of Lead Candidates for CNS Disorders
Lars Sundstrom and Luc Stoppini,
Capsant Neurotechnologies
Presenting Author: Luc Stoppini, Capsant Neurotechnologies - UK

P02005 - Cell Type Specificity for ATF-2 Activation
Amy M. Peters and Jeffrey R. Haskins,
Cellomics, Inc.
Presenting Author: Amy Peters, Cellomics Inc. - USA

P02006 - Multiplexed High Content Screens and Advanced Reagents
D. Lansing Taylor and Kenneth A. Giuliano,
Cellumen, Inc.
Presenting Author: D. Lansing Taylor, Cellumen, Inc. - USA

P02007 - Quantitative Characterization of Mitosis-Blocked Tetraploid Cells Using High Content Analysis
Richik N. Ghosh, and Linnette E. Grove,
Cellomics, Inc.
Presenting Author: Richik Ghosh, Cellomics, Inc. - USA

P02008 - SNAP-tag™ The Swiss Army Knife of Covalent Protein Labeling and Modification
A. Brecht, C. Dossenbach, M. Schwab and R. Tynes,
Covalys Biosciences AG
Presenting Author: Andreas Brecht, Covalys Biosciences AG - Switzerland

P02009 - G1S Checkpoint Reporting
Simon Stubbs, Suzanne Hancock, Hayley Tinkler, Nick Thomas, Paul Michael, Stephen Capper, Michael Kenrick, Iain Bye and Dwayne Dexter,
GE Healthcare,
Jinming Gu and Ellen Fanning,
Vanderbilt University
Presenting Author: Suzanne Hancock, GE Healthcare - UK

P02010 - Standards for Accurate Flat-field Calibration in Wide-field Fluorescence Microscopy
Zahra Masoumi, Ahmad Yekta and Joseph Masino,
GE Healthcare
Presenting Author: Zahra Masoumi, GE Healthcare - USA

P02011 - Using IN Cell Analyzer 1000 to Characterize Flatness of Plate and Well Bottoms
Zahra Masoumi, Mark Campion, Ahmad Yekta and Joseph Masino,
GE Healthcare
Presenting Author: Zahra Masoumi, GE Healthcare - USA

P02012 - IN Cell Developer, A Flexible Software Toolbox for Analyzing Cellular Images in Automated High Content Screening - Examples of Applications
Alla Zaltsman, Geert Kalusche, Kyosuke Haze (Japan , Banyu Pharmaceutical Co., Ltd.), Takayoshi Okabe (Japan , Banyu Pharmaceutical Co., Ltd.), Noriko Oshima, Iain Bye and Liz Roquemore,
GE Healthcare
Presenting Author: Liz Roquemore, GE Healthcare - UK

P02013 - A Quantitative, Automated, High Content Screening Assay for Angiogenic Tube Formation
Linnette E. Grove, Oleg Lapets, and Richik Ghosh,
Cellomics, Inc.
Presenting Author: Linnette Grove, Cellomics, Inc. - USA

P02014 - Quantifying Image Quality and its Influence on HCS Data
Ahmad Yekta, Zahra Masoumi, Richard McKay and Joseph Masino,
GE Healthcare
Presenting Author: Ahmad Yekta, GE Healthcare - USA

P02015 - Fragment Screening on Chemical Microarrays using SPR Imaging Technology
Thomas Neumann, Oliver Hill, Klaus Burkert, Hans-Dieter Junker, Kerstin Otte, Meinolf Thiemann, Renate Sekul, Jürgen Gamer and Kristina Schmidt,
Graffinity
Presenting Author: Thomas Neumann, Graffinity - Germany

P02016 - Implementing a Technologically Integrated Approach to the Evaluation of Kinetic Cell Signalling
Peter B. Simpson, Grace K.Y. Chan, Sally-Anne Thompson, Amy Platts, Mary Duncan, Kathy G. Sutton, Fahd Choudhry, Keith A. Wafford, Gillian R. Richards and Vahri Beaumont
Merck Sharp & Dohme
Presenting Author: Peter Simpson, Merck & Co. - United Kingdom

P02017 - Simultaneous Image Analysis of Multiple Apoptotic Pathways
Neal Gliksman and Paula Rickert,
Molecular Devices Corporation
Presenting Author: Neal Gliksman, Molecular Devices Corporation - USA

P02018 - High Content Screening of Red Blood Cell Differentiation and Cytotoxicity using an Acumen Explorer
Debra Taylor, Barbara Saxty, Alison Levy, Marie-Alice Deville (MRC Hematology Unit), Paul Wylie (TTP LabTech),
MRC Technology
Presenting Author: Debra Taylor, MRC Technology - UK

P02019 - Screening of Biologically Active Marine Natural Products in PIBOC
Dmitry Aminin, Michael Anisimov, Nina Prokof'eva, Irina Agafonova, Galina Likhatskaya and Valentin Stonik,
Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Presenting Author: Dmitry Aminin, Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences - Russia

P02020 - LumiLux™ -The New Luminescence Cellular Screening Platform for Assay Development and Ultra High Throughput Screening
Claire Hooper, Pavan Sanotra, Sofia Vikstrom and Janet Park,
PerkinElmer Life and Analytical Sciences
Presenting Author: Claire Hooper, PerkinElmer LAS - UK

P02022 - High- throughput (HTP) Small Animal MRI at 3 Tesla
Ray Nunnally, Jolinda Smith, Scott Watrous,
University of Oregon
Presenting Author: Ray Nunnally, University of Oregon - U.S.A.

P02023 - Small Animal Imaging with High Resolution at 3 Tesla
Ray Nunnally, Jolinda Smith, Scott Watrous,
University of Oregon
Presenting Author: Ray Nunnally, University of Oregon - U.S.A.

P02024 - Latent Fluorophores Based on the Trimethyl Lock
Luke Lavis, Sunil Chandran, Kimberly Dickson, and Ronald Raines,
University of Wisconsin-Madison
Presenting Author: Luke Lavis, University of Wisconsin-Madison - USA

P02025 - Comparison of Several Classes of Algorithms for Cytoplasm to Nucleus Translocation
Ilya Ravkin and Vladimir Temov,
Vitra Bioscience, Inc.
Presenting Author: Ilya Ravkin, Vitra Bioscience - USA

P02026 - CellProfiler™: Free Cell Image Analysis Software for High Throughput Screening
Anne E. Carpenter, Thouis R. Jones, Polina Golland and David M. Sabatini,
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Presenting Author: Anne Carpenter, Whitehead Institute for Biomedical Research - USA

P02028 - The Optical LiveCell® Array - a Novel Tool for High Content Analysis of Adhering and Non-Adhering Living Cells at the Individual Cell Resolution: Applications for Beta Cell Research
Orian Shirihai, Hibo Mohamed, Stephen Katz,
Tufts Medical School,
Naomi Zurgil, Motti Deutsch,
Bar-Ilan University,
Barbara Corkey,
Boston University,
Israel Biran,
Molecular Cytomics Inc.
Presenting Author: Israel Biran, Molecular Cytomics Inc. - US

P02029 - Image-based High-content Screening of Fatty Acid Uptake
Richard Sportsman, Mary David, Neal Gliksman, Joe Bosworth, Linnea Hager and Paula Rickert,
Molecular Devices Corporation
Presenting Author: Richard Sportsman, Molecular Devices Corporation - USA

P02030 - High-content Data Analysis for a Primary-, Confirmation- and Profiling-screen. A Case Study on Multiparametric uHTS Cell Imaging Data
Stefan Jaeger and Martin Daffertshofer,
Evotec Technologies,
Stephan Heyse, Oliver Duerr and Annette Brodte,
Genedata
Presenting Author: Stefan Jaeger, Evotec Technologies - Germany

P02031 - Fluorescence Imaging and Photon Statistics - Advantages of Combined Intracellular Characterizations
Stefan Jaeger, Karsten Kottig, Andreas Fetsch and Martin Daffertshofer,
Evotec Technologies
Presenting Author: Stefan Jaeger, Evotec Technologies - Germany

P02032 - Measuring Growth Factor-stimulated Cell Scattering using the IN Cell Analyzer 1000
Robert Graves,
GE Healthcare Bio-Sciences,
Bart Lutterbach, Ilona Kariv and Alexander Szewczak,
Merck Research Laboratories
Presenting Author: Robert Graves, GE Healthcare Bio-Sciences - USA

P02033 - Improved HIT Quality by Parallel HTS Strategy and Early Genotoxicity Profiling
François Duval, Anthony Nichols, Didier Leroy, Dominique Perrin, Alexander Scheer and Paul Lang,
Serono International SA SPRI
Presenting Author: François Duval, Serono International SA SPRI - Switzerland

P03001 - Automation of the Luminescent Based P450-Glo CYP3A4 and 2C9 Inhibition Assay with Human Liver Microsomes
Gisela Backfisch and Susann Brixner,
Abbott GmbH & Co KG,
Ron Aoyama and Steve Morfitt,
Abbott Laboratories,
Brad Larson and Tracy Worzella,
Promega Corporation
Presenting Author: Gisela Backfisch, Abbott GmbH & Co. KG - Germany

P03002 - The ELx405™ Washer: A Family of Washers to Meet the Diverse Needs of Biological Screening
Paul Held and Andreas Rieger,
Bio-Tek Instruments, Inc.
Presenting Author: Paul Held, Bio-Tek Instruments - USA

P03003 - Monitoring of Microbial Growth Curves by Laser Nephelometry
Silke Angersbach, Bernd Hipler, Sven Brand (University Bielefeld) and Christian Rückert (University Bielefeld),
BMG LABTECH
Presenting Author: Marjan Orban, BMG LABTECH GmbH - Germany

P03004 - Use of the PHERAstar for SNP Genotyping Chemistry Development and High-Throughput Production Genotyping
Phil Robinson,
KBiosciences
Presenting Author: Marjan Orban, BMG LABTECH GmbH - Germany

P03005 - Pharmacological Characterization of 5-Hydroxytryptamine2b Receptor in Evaluation of Aequorin for Miniaturized G-protein-coupled Receptor High Throughput Screening
Mark A. Gilchrist II, Angela Cacace, George Hansen, and David G. Harden,
Bristol-Myers Squibb Company
Presenting Author: Mark Gilchrist II, Bristol-Myers Squibb Company - United States

P03006 - The Making of Novel Artificial Meganucleases Derived from Homing Endonucleases to Induce Homologous Recombination in Living Cells
Jean-Charles Epinat, Patrick Chames, Sylvain Arnould, Emmanuel Lacroix, Aymeric Duclert, Philippe Duchateau and Frédéric Paques,
CELLECTIS, S.A.
Presenting Author: Jean-Charles Epinat, CELLECTIS - France

P03007 - CytoPatch™ Automated Patch Clamp for hERG Pharmacology
Christa Nutzhorn, Thomas Knott, Timm Danker and Alfred Stett,
Cytocentrics AG
Presenting Author: Christa Nutzhorn, Cytocentrics AG - Germany

P03008 - High-Throughput Automation of a Dual Reporter Assay in Low-Volume 384 & 1536-Well Plate Formats using the Deerac Fluidics’ Equator HTS- Eight Tip Pipetting System, Promega’s Chroma-Luc Technology, and BMG LABTECH’s PHERAstar Microplate Reader
Rod Haroutunian and Aoife Gallagher,
Deerac Fluidics
Brad Larson, Tracy Worzella and Michael Bjerke,
Promega Corporation
Ed Matthews,
BMG Labtech
Presenting Author: Rod Haroutunian, Deerac Fluidics - Ireland

P03009 - Live Cell Monitoring - System for Cultivation and Monitoring of Living Cells
Christian Hoffmann, Dominik Giel, Albrecht Brandenburg, Dirk Malthan (Fraunhofer IPA), Ron Schwarz (Fraunhofer FIT) and Hagen Thielecke (Fraunhofer IBMT),
Fraunhofer IPM
Presenting Author: Christian Hoffmann, Fraunhofer Institute for Physical Measurement Techniques IPM - Germany

P03010 - Interferometer for Label-free Detection of Biomolecules in MTP Format
Katrin Schmitt, Bernd Schirmer, Christian Hoffmann and Albrecht Brandenburg,
Fraunhofer IPM
Presenting Author: Katrin Schmitt, Fraunhofer IPM - Germany

P03011 - Implementation of Tecan’s Cellerity™ Automated Cell Culture Workstation at Genentech
JP Stephan, S Frankovitz, A Wong, P Chan,
Genentech, Inc.
Presenting Author: Jean Philippe Stephan, Genentech, Inc. - USA

P03012 - Development of a High Throughput FLIPR Assay of the C3a Complement Receptor Using a Dual-BacMam Transfection Strategy
Stephen Brough, Caroline Brough, Emma Koppe and Alan Wise,
GlaxoSmithKline
Presenting Author: Stephen Brough, GlaxoSmithKline - UK

P03013 - Competitive Immunoassay for in CD Microlaboratories Allows for Miniaturized, Fast and Sensitive Quantification of ow-molecular Weight Compounds
Helene Dérand, Mats Holmquist, Bo Ek, Mats Inganas and Bobbi O’Hara (Assay Designs, Inc.),
Gyros AB
Presenting Author: Helene Dérand, Gyros AB - Sweden

P03014 - Increasing Plate Washer Throughputs with Modified Pump Capacity
Michael S. Routburg, Efren D. Romero, Paul B. Taylor, and Carol A. Homon,
Boehringer Ingelheim Pharmaceuticals Incorporated
Presenting Author: Paul Taylor, Boehringer Ingelheim - USA

P03015 - Improving Quality of Biological Assays: Advantages of Direct nl Compound Dispense
Marina Nelen, Kannan Ramachandren and Matthew Todd,
Johnson & Johnson Pharmaceutical Research & Development, L.L.C
Presenting Author: Marina Nelen, Johnson & Johnson PRD - USA

P03016 - Industrializing the Hybridoma Development Process: From Mouse to Monoclonal
Denise Williams, Brigitte Devaux, Dermot Mee and Bill Koukis,
Medarex Inc.
Presenting Author: Denise Williams, Medarex Inc. - USA

P03017 - A High Specification Dual Arm Robot Screening Platform Designed for Flexible Operation
Kevin Moore, Grace KY Chan, Clare Leech and Peter B Simpson,
Merck Sharp & Dohme
Karen Allison, Kelly Warrington and Mel Whiteside
RTS Life Science
Presenting Author: Kevin Moore, Merck Sharp & Dohme - UK

P03018 - Micro Fluidic Flow Control in Life Science Applications
Juerg Gentsch,
Novartis Institutes for BioMedical Research,
Rudolf Buser, Markus Nigg, Sabrina Widmer, Martin Bless and Marcel Sutter,
Interstate University of Applied Sciences of Technology Buchs
Presenting Author: Juerg Gentsch, Novartis Institutes for BioMedical Research - Switzerland

P03019 - AcroPrep™ 96 Filter Plates Reduce the Presence of False Positive Results in Serological Based Immunoassays with Luminex® xMAP® Technology
Emily Berlin, Harold Baker (Luminex Corporation) and Sonya Lowrance (Luminex Corporation),
Pall Life Sciences
Presenting Author: Emily Berlin, Pall Life Sciences - USA

P03020 - Flexible Microplate Assay Automation using the Evolution P3 with Modular Dispense Technology
Robert Stanaker, Michael Kealy,
Perkin Elmer Life and Analytical Sciences
Presenting Author: Michael Kealy, Perkin Elmer Inc. - USA

P03021 - Automation of a GPCR Cell-based Functional Assay on the Cellular Workstation System using the LANCE cAMP Technology
Steve Hurt, Harry Harney, Hanh Le, Robert Stanaker, Chantal Illy, and Rajesh Manchanda,
PerkinElmer Life and Analytical Sciences
Presenting Author: Stephen Hurt, PerkinElmer LAS - USA

P03022 - LANCE™ cAMP + Evolution™ P3 + ViewLux™ = uHTS
Patricia Kasila, Hao Xie, Harry Harney, Andy Raneri, Greg Warner,
PerkinElmer Life and Analytical Sciences
Presenting Author: Greg Warner, PerkinElmer Life and Analytical Sciences - USA

P03023 - High Throughput Nanoliter Dispensing Using NanoHead™ Technology
Nance Hall, Len Dugad and James Clark,
PerkinElmer Life and Analytical Sciences, Inc.
Presenting Author: Nance Hall, PerkinElmer Life and Analytical Sciences, Inc. - USA

P03024 - Activity Measurement of TNF-α Converting Enzyme (TACE) in 3456-Well Nanoplate Format
Michael Bohanon, Molly Hood, Chiu-Fai Man, Piet de Dreu, Scott Wise, Tim Braden and Adam Johnson,
Pfizer, Inc.
Presenting Author: Michael Bohanon, Pfizer - USA

P03025 - Centralized vs. Multi-Site Compound Management
Donat Elsener and Scott Reeves,
REMP
Presenting Author: Donat Elsener, REMP - Switzerland

P03026 - How Many Control Wells are Required to Accurately Estimate Z'-Factor
Bruce D. Koch and Cheng Su,
Roche Palo Alto
Presenting Author: Bruce Koch, Roche Palo Alto - USA

P03027 - High Speed Single Use 384 Tube Technology - Avoiding The Freeze/Thaw Cycle
Chris Walsh, Kirk Hilton and Nick Harrison,
RTS Life Science
Presenting Author: Kelly Warrington, RTS Life Science - UK

P03028 - Secure Storage and Retrieval of Samples under Controlled Environmental Conditions
Mike Pollard, Sheenaanne Law and Colin Hague,
RTS Life Science
Presenting Author: Kelly Warrington, RTS Life Science - UK

P03029 - Effective Miniaturized Workstation Screening with 50 nl 'Ready-to-use' Compound Plates
Christian Bergsdorf and Ulf Bömer,
Schering AG
Presenting Author: Christian Bergsdorf, Schering AG - Germany

P03030 - Automated Optimization and Analysis using QuickQuan for LC/MS
Joseph Senteno, Louis Maljers and Marta Kozak,
Thermo Electron Corporation
Presenting Author: Marta Kozak, Thermo Electron Corporation - USA

P03031 - An Ultra-High Throughput Approach to High Content Screening in 1536-Well Format
Yan Wang, Robert Davis (Kalypsys, Inc.) and Wayne Bowen,
TTP LabTech Ltd
Presenting Author: Wayne Bowen, TTP LabTech Limited - UK

P03032 - High-Throughput Automated High Content Screening using a BioCube System and Microplate Cytometry
Wayne Bowen (TTP LabTech Ltd), Jason Quarles and Michael Catalano,
Protedyne Corporation
Presenting Author: Sarah Payne, TTP LabTech Limited - UK

P03033 - Robot System for Automated Drug Screening on Xenopus Oocytes
Igor Baburn, Beyl Stanislav, Sophia Khom, Steffen Hering,
University Vienna
Presenting Author: Igor Baburin, University Vienna - Austria

P03034 - An Automated LC/MS/MS Protocol To Enhance Throughput Of Physico-Chemical Property Profiling In Drug Discovery
Darcy Shave, Peter G. Alden, Kate Yu, Rob Plumb and Warren Potts,
Waters Corp.
Presenting Author: Darcy Shave, Waters Corporation - USA

P03035 - Development of a Single Use Plate for Compound Storage-Distribution and Miniaturized Assays
Paul B. Taylor, E. Michael August, Richard D. Belval, Mohammed A. Kashem, Jonathan Lipsky, Eugene Margolin, Scott Morley, Efren D. Romero, Michael S. Routburg, Donna Terenzio, Stephen Young and Carol A. Homon,
Boehringer Ingelheim Pharmaceuticals Inc. and Innovative Microplate
Presenting Author: Paul Taylor, Boehringer Ingelheim Pharmaceuticals Inc. - USA

P03036 - Luxcel Phosphorescent Label Technology for screening and IVD Applications
Dmitri B. Papkovsky and Tomas C. O’Riordan (University College Cork, Ireland) ,
Luxcel Biosciences, Ltd.
Presenting Author: Dmitri Papkovsky, Luxcel Biosciences Ltd. - Ireland

P03037 - Nanoliter Dispensing of Compounds into Assay Plates using Disposable PocketTips™
Sébastien Guiral, Frédéric Massé, Jeff Karg (nAscent Biosciences Inc.), Doug Kroncke (nAscent Biosciences Inc.) and Christine Brideau,
Merck Frosst Centre for Therapeutic Research
Presenting Author: Brideau Christine, Merck Frosst Canada & Co. - Canada

P03038 - Compound transfer to 3456-well assay plates using the Echo™ 550
Frédéric Massé, Sébastien Guiral, Shiraz Adam, Stacia Kargman and Christine Brideau,
Merck Frosst Centre for Therapeutic Research
Presenting Author: Stacia Kargman, Merck Frosst Canada & Co. - Canada

P03039 - A Flexible, High-throughput, Cost Effective Robotics Solution for HTS
William Goode, John Munro and Adam Hill,
Novartis Institutes for Biomedical Research
Presenting Author: William Goode, Novartis Institutes for Biomedical Research - USA

P03040 - Automated Multiplexed Cell-Based Assays for High-Throughput Drug Discovery
Brad Larson, Tracy Worzella, Siegfried Sasshofer (Tecan), Aoife Gallagher (Deerac Fluidics),
Promega Corp.
Presenting Author: Brad Larson, Promega Corp. - USA

P03041 - Optimization of Biomek FX Multidispensing Liquid Handling Parameters
Ginger Smith, Katja Remlinger, Jim Liacos, Cathy Finlay and Jimmy Bruner,
GlaxoSmithKline
Presenting Author: Ginger Smith, GlaxoSmithKline - USA

P03042 - Mass Spectrometry-based Enzyme Assays for Rapid Inhibitor Screening
S. Zhou, G. Davis, E. Dolan, T. Burt, A. Evdokimov, V. Easwaran, J. Roesgen, R. Kawamoto, A. Carr, and K. Greis,
Procter & Gamble Pharmaceuticals
Presenting Author: Kenneth Greis, Procter & Gamble Pharmaceuticals - USA

P03043 - A Method for Factorial Design of GTPγS Assays for Screening
Linda Nilsson, Bengt Kull and Peter Greasley,
AstraZeneca
Presenting Author: Linda Nilsson, AstraZeneca - Sweden

P03044 - Extending High Content Analysis to Animal Models of Injury
Megan Cuda, Jason Callio (University of Pittsburgh School of Medicine) and Charleen Chu (University of Pittsburgh School of Medicine), Lisa Reuter, Everett Ramer and Jeffrey R. Haskins,
Cellomics, Inc.
Presenting Author: Megan Cuda, Cellomics Inc. - USA

P03045 - Automated Dispensation of Yttrium Oxide SPA Imaging Beads, into 1536-Well Plates using the Deerac Fluidics’ Equator™ HTS - Eight Tip Pipetting System.
Aoife Gallagher,
Deerac Fluidics,
Mike Looker and Ruth Waythe,
GE Healthcare
Presenting Author: Aoife Gallagher, Deerac Fluidics - Ireland

P03046 - Compound Concentration and the Effect of the Tecan Genesis. Methods used to Minimize Dilution Effects
Brian Lupotsky, Sue Holland, Terrence Johnson, Robert Hughes, Stephen Trowbridge, Darren Rimmer, Trevor Dye, Ken Murray, Zoe Blaxill, Steve Besley, Rob Lifely, Zofia Huckins and Donald Lyerly,
GlaxoSmithKline
Presenting Author: Brian Lupotsky, GlaxoSmithKline - USA

P03047 - uHTS Campaign of an Enzyme in Kinetic Mode Offers High Information Content and In-well QC Monitoring
Laura Vela, Ana Roa, Alberto Alaminos, Juan A. Mostacero, Manolo Valmaseda and Julio Martin,
GlaxoSmithKline
Presenting Author: Laura Vela, GlaxoSmithKline - Spain

P03048 - Pharmaceutical Compound Collection Profiling with Direct LC/MS Analysis
John P. Walsh, Daniel Sipes, Paul Queeney, Andy Martin, Paul Nyffeler and Robyn A. Rourick,
Kalypsys, Inc.
Presenting Author: John Walsh, Kalypsys, Inc. - USA

P03049 - Combining Blue and Red Bioluminescence for Multiplexed Analysis in Living Cells
Keith V. Wood, Nancy Murphy, and Erika Hawkins,
Promega Corporation
Presenting Author: Keith Wood, Promega Corporation - USA

P03050 - Homogenous Functional Assay for HTS-based Identification of Gα-S Protein Coupled Receptor Agonists
Yves Cambet, Raphaele Foulle, Artush Yeghiazaryan, Holger Heine, Dominique Besson, Alexander Scheer and Didier Leroy,
Serono Pharmaceutical Research Institute
Presenting Author: Yves Cambet, SERONO - Switzerland

P03051 - Ultra rapid Competent Cells for High-throughput Protein Expression.
Steve Richmond, Laura Moody, Nicola Latchem and Mark Truesdale,
Genetix Ltd.
Presenting Author: Mark Truesdale, Genetix Ltd - UK

P04001 - Quantitative and High Throughput Screening of Tumor Cell Invasion using a Novel Cell-based Model
Jeff Partridge and Susan Qian,
BD Biosciences
Presenting Author: Jeff Partridge, BD Biosciences - USA

P04002 - Fluorescent HTS assay for Glycosyltransferases
Randy Bolger, Matt Staeben, Karen Kleman-Leyer, Thane Westermeyer, and Robert G. Lowery,
BellBook Labs
Presenting Author: Randy Bolger, BellBrook Labs - USA

P04003 - Is DMSO a Friend - or a Troublemaker
Agneta Tjernberg, Natalia Markova and Dan Hallén,
Biovitrum AB
Presenting Author: Agneta Tjernberg, Biovitrum AB - SWEDEN

P04004 - Novel Chemical Proteomics Platform, Chip'N'Fish™, For Rapid Identification of Small Molecule Drug Candidates Against Disease-specific Targets
Laszlo Urge, Gyorgy Dorman, Janos Gerencser, Ferenc Darvas, Laszlo Puskas (Laboratory of Functional Genomics, Biological Research Center), and Zsolt Lorincz (RecomGenex Ltd.),
ComGenex, Inc.
Presenting Author: Laszlo Urge, ComGenex, Inc. - Hungary

P04005 - Methods to Improve the Success of High Throughput Cell-based Assays
Michael W. Briggs, Pilar Pardo and Alice Gao,
Corning Life Sciences
Presenting Author: Michael Briggs, Corning Life Sciences - USA

P04006 - Applications of Reverse Transfection Cell Arrays
Brian Webb, Fawad Faruqi, Wanda Walczak, Elizabeth Tran, Meenal Soni, Mark Lewis, and Todd Upton,
Corning Incorporated
Presenting Author: Brian Webb, Corning, Inc. - USA

P04008 - Rapid Transcription Factor Binding Analysis
Scott Hayes and Faye Bruggink,
EMD Biosciences, Inc.
Presenting Author: Scott Hayes, EMD Biosciences, Inc. - USA

P04009 - High Content Analysis of a Reverse Transfection siRNA Screen using a Cell Line Reporting G1-S Cell Cycle Transition
Simon Stubbs, Suzanne Hancock, Devin Leake (Dharmacon) and Nick Thomas,
GE Healthcare
Presenting Author: Nick Thomas, GE Healthcare - UK

P04010 - High Throughput Technology Bringing Routine Quantitation to Chemistry and Screening: A Comparison of Three Detection Strategies: - Evaporative Light Scattering, Chemiluminescent Nitrogen and Proton NMR
Zoe Blaxill, Carol Carmody, Duncan Farrant, Clare Holyoak, Ian Mutton,
GlaxoSmithKline
Presenting Author: Zoe Blaxill, GlaxoSmithKline - UK

P04011 - High Frequency Focused Acoustic Technology: Evaluation for Compound Mixing and Dissolution
Jon Curtis, Zoe Blaxill, Adrian Pipe, James Chan, Karen Dobbs, Todd Graybill and Suzanne Baddeley,
GlaxoSmithKline,
Jim Laugharn,
Covaris
Presenting Author: Jon Curtis, GlaxoSmithKline - UK

P04012 - High-Throughput Profiling of Gene Expression with Arrays in Microplates
Ralph Martel, Ihab Botros, Matthew Rounseville and Bruce Seligmann,
High Throughput Genomics, Inc.
Presenting Author: Ralph Martel, High Throughput Genomics, Inc. - USA

P04013 - Bioinformatics Tool for Mutational Screening: Possible Application in Prediction of Response to Cancer Therapies
Nevena Veljkovic and Vladimir Perovic,
Institute for nuclear Sciences VINCA
Presenting Author: Vladimir Perovic, Institute for nuclear Sciences VINCA - Serbia and Montenegro

P04014 - Synthesis And Biological Evaluation Of Some Novel 1,3,4 Oxadiazole Derivatives from Aromatic Acid Hydrazides
M.Shahar yar Siddiqui, Anees .A. Siddiqui and Ashraf Ali,
Jamia Hamdard-University
Presenting Author: Mohamed Shahar Yar Siddiqui, Jamia hamdard university - india

P04015 - Synthesis and Biological Evaluation of some Novel Pyrazoline Derivatives from Novel Chalcones Treated with Aromatic Acid Hydrazides
M.Shaharyar Siddiqui, Anees .A. Siddiqui, Ashraf Ali,
Jamia Hamdard-University
Presenting Author: Mohamed Shahar Yar Siddiqui, Jamia hamdard university - india

P04016 - Analysis of Endogenous Growth Factor Receptor Activity in Mammalian Cancer Cell Lines using a Label-Free Live-Cell Based Assay
Yen-Wen Chen, Edward Verdonk, Gordon Leung, H. Roger Tang, Ryan McGuinness and Julia M. Michelotti,
MDS Sciex
Presenting Author: Yen-Wen Chen, MDS Sciex - USA

P04017 - Development of a Label-Free Cellular Assay for an Endogenously-Expressed GPCR using Cellular Dielectric Spectroscopy
Anne T. Ferguson, Debra Gallant, Ryan McGuinness and Gordon Leung,
MDS Sciex,
Yuanping Wang, Jenson Qi and Lisa Minor,
Johnson & Johnson, PRD
Presenting Author: Anne T. Ferguson, MDS Sciex - usa

P04018 - Investigating the FcERI Receptor Signaling Pathway and Mast Cell Degranulation using a Novel Label-free Cell-based Assay Technology
Gordon Leung, Yen-Wen Chen, Ed Verdonk, Ryan McGuinness and Debra Gallant,
MDS Sciex
Presenting Author: Gordon Leung, MDS Sciex - USA

P04019 - Complex Signaling Pathway Analysis and Pharmacological Profiling of an Important GPCR Using Cellular Dielectric Spectroscopy, A Novel Cellular Assay Platform
Ryan McGuinness, Uma Oza, Gordon Leung and Vivian Liu,
MDS Sciex,
Ralph Garippa, Theresa Truitt and David Mark,
Hoffmann LaRoche
Presenting Author: Ryan McGuinness, MDS Sciex - usa

P04020 - Cataloging Endogenous Cell Surface Receptors and Analyzing Their Functional Activity using Label-free Cellular Dielectric Spectroscopy
Edward Verdonk, Gordon Leung, Vivian F. Liu, H. Roger Tang, Ryan McGuinness Yen-Wen Chen and Julia Michelotti,
MDS Sciex
Presenting Author: Edward Verdonk, MDS SCIEX - USA

P04021 - Identification of New HDAC Inhibitors from Microbial Extract Screening
H. Flotow, A. Ngo, M.S. Butler, K. Yoganathan, and A.D. Buss,
MerLion Pharmaceuticals,
P. Marcotte, K. Glaser, U. Warrior, J. Hochlowski and D. Burns,
Abbott Laboratories
Presenting Author: Horst Flotow, Merlion Pharmaceuticals - Singapore

P04022 - Vascular Injury Biomarkers: Multiplexed Immunoassays
Abrehet Abdu, Jeff Debad, Selen Stromgren, Martin Stengelin, John Joern and Eli N. Glezer,
Meso Scale Discovery
Presenting Author: Abrehet Abdu, Meso Scale Discovery - USA

P04023 - Cardiac Biomarker Assays
Jeff Debad, Abrehet Abdu, and Eli Glezer,
Meso Scale Discovery
Presenting Author: Jeff Debad, Meso Scale Discovery - USA

P04024 - Metabolic Marker Assays: Adiponectin, Glp-1, Insulin, Leptin, Resistin
Selen A. Stromgren, Michael Tsionsky, Tatiana Plissova, Anu Mathew, and Eli N. Glezer,
Meso Scale Discovery
Presenting Author: Selen Stromgren, Meso Scale Discovery - USA

P04025 - Fluorescence Microplate Assays for Analysis of the Chlorination and Peroxidation Activities of Myeloperoxidase
Yue Ge and Iain Johnson,
Molecular Probes Invitrogen Detection Technologies
Presenting Author: Yue Ge, Molecular Probes Invitrogen Detection Technologies - USA

P04026 - The Neurogenesis Qualifier Discovery Platform for Therapeutic Neurogenesis
Jarkko Kortesmaa,
NeuroNova AB
Presenting Author: Jarkko Kortesmaa, NeuroNova AB - Sweden

P04027 - Development and Validation of a High Throughput Screen for Inhibitors of HhaI Methyltransferase
Sandra Bruno, Jeremy Jenkins, W. Adam Hill and Christian N. Parker,
Novartis Institutes for BioMedical Research, Inc.
Presenting Author: Adam Hill, Novartis - USA

P04028 - Development of Cell-Based Assays for Screening and Evaluating Anti-Dengue Agents
Qing-Yin Wang, Wouter Schul, Haoying Xu, Wei Liu, Gerald Kleymann and Subhash G. Vasudevan,
Novartis Institute For Tropical Diseases
Presenting Author: Qing-Yin Wang, Novartis Institute for Tropical Diseases - Singapore

P04029 - Identifying Galanin Type 1 Antagonists using a Functional Luciferase Reporter Assay as a Primary Screen
M. Speake, F. Thomson, K. Goan, A.E. Kisilevsky and S. Napier,
Organon Laboratories Ltd.
Presenting Author: Michael Speake, Organon laboratories - UK

P04030 - Validation of the DiscoveRx EFC cAMP Assay for Screening at the Human ORL1 Receptor
A Sutherland, M Deehan, S. Gardner and H. Sundaram,
Organon Laboratories Ltd.
Presenting Author: Aaron Sutherland, Organon Laboratories - Scotland

P04031 - Development of a Homogenous cGMP Phosphodiesterase Assay
Martin Boissonneault, Christian Fafard, Joe Trometer (PerkinElmer LAS), Chantal Illy and Roger Bossé,
PerkinElmer BioSignal Inc.
Presenting Author: Roger Bossé, PerkinElmer BioSignal Inc. - Canada

P04032 - High Throughput Characterization of Monomeric GTPases of the Ras Superfamily
Michael Lassle,
PerkinElmer LAS GmbH,
Sara Jenna, Marie-Elaine Caruso, Eun Hye Lee and Eric Chevet,
MGill University,
Simon Beaulne and Cédric Chauve,
Université du Québec à Montréal (UQUAM),
Annick Bergeron,
Université de Montréal,
Jean-François Rual, DE Hill and Marc Vidal,
Dana-Farber Cancer Institute,
Philippe Roby and Roger Bossé,
PerkinElmer BioSignal Inc.
Presenting Author: Michael Lassle, PerkinElmer LAS GmbH - Germany

P04033 - Targeting the MurC Bacterial Enzyme for Antimicrobial Therapeutic Intervention
Laura Zawadzke, Michael Norcia,
Pfizer
Presenting Author: Laura Zawadzke, Pfizer - USA

P04034 - Profiling Serum Proteins with SearchLight Multiplex Protein Array
Bo Lin, Scott Van Arsdell, and Christine Burns,
Pierce Biotechnology, Inc.
Presenting Author: Bo Lin, Pierce Biotechnology - USA

P04035 - Measuring Drug Solubilities at 37°C
Gabriela Cimpan, Karl Box, John Comer and Steve Stones (Heath Scientific),
Sirius Analytical Instruments Ltd.
Presenting Author: Gabriela Cimpan , Sirius Analytical Instruments Ltd - England

P04036 - Development, Validation and Screening for Inhibitors of Severe Acute Respiratory Syndrome Coronavirus in a Luminescence-Based High Throughput Screen
E. Lucile White, Nice Shindo, Melinda I. Sosa, Thomas Rowe, Jeff Hogan, Nicole Kushner, Barbara Taggart, Michael McDowell, Jenny Todd, Sara Cooley, Anna Manouvakova, Thomas M. Fletcher III, Victor E. Buckwold, Colleen B. Jonsson,
Southern Research Institute
Presenting Author: Lucile White, Southern Research Institute - USA

P04037 - Expression of Cathepsin D and E Cadherin in Relation to Clinical Prognostic Factors of Endometrial Cancer
George Burkadze, Gulisa Turashvili and Irina Dvalishvili (National Cancer Center of Georgia),
Tbilisi State Medical University
Presenting Author: George Burkadze, Tbilisi State Medical University - Georgia

P04038 - Campylobacter Enteritis among Children in Iran
M.H. Shirazi and M.R. Pourmand,
Tehran University of Medical Sciences
Presenting Author: Mohammad Hassan Shirazi, Tehran University of Medical Sciences - Iran

P04039 - Bimolecular Assays on Label-independent HTS System
Yan Kong, Mannix Aklian(Corning), Darpana Patel, Thomas Lynch (Corning) and Mary Jo Wildey,
The R.W. Johnson PRD
Presenting Author: Yan Kong, The R.W. Johnson PRD - USA

P04040 - Determination of Lanthanide Lifetimes with Varioskan
Jorma Lampinen and Marika Raitio,
Thermo Electron Corp.
Presenting Author: Jorma Lampinen, Thermo Electron - Finland

P04041 - Measuring the Physiological Effects of RNAi in a Heterogeneous Population of Non-Adhering Cells at the Single Cell Resolution Using the Optical LiveCell® Array Technology
Brigham Hyde, Sarah Haigh and Orian Shirihai,
Tufts Medical School,
Naomi Zurgil and Motti Deutsch,
Bar-Ilan University,
Israel Biran,
Molecular Cytomics Ltd.
Presenting Author: Brigham Hyde, Tufts Medical School - USA

P04042 - A High-throughput Screening Assay for CB1 Receptor Modulators
Nathalie Lambeng, Bruno Fuks, Michaëlla Grossmann, Anne Vandendriessche, Luc Quéré and Maggi Burton,
UCB S.A.
Presenting Author: Nathalie Lambeng, UCB - Belgium

P04043 - Screening of Drug-lipid Interactions : Comparison between Biacore® and IAM-HPLC
Christian Wolff, Luc Quere and Pierre Chatelain,
UCB S.A.
Presenting Author: Christian Wolff, UCB S.A. - Belgium

P04044 - New Assay for Histone Methyltransferases
Manfred Jung, Astrid Spannhoff,
University of Freiburg
Presenting Author: Manfred Jung, University of Freiburg - Germany

P04045 - Novel Homogenous Non-competitive Immunoassay for Haptens
Tiina Kokko, Leena Kokko and Tero Soukka,
University of Turku
Presenting Author: Tiina Kokko, University of Turku - Finland

P04046 - Novel Homogeneous Assay Technology Based on Up-converting Phosphors
Katri Kuningas, Terhi Rantanen, Telle Ukonaho, Timo Lövgren and Tero Soukka,
University of Turku
Presenting Author: Katri Kuningas, University of Turku - Finland

P04047 - High Throughput Profiling of siRNA and miRNA Libraries using Microplate Cytometry
Wayne Bowen (TTP LabTech Ltd), Angie Cheng, Mike Byrom, Lily Rosa, Stephanie Brooking and Lance Ford,
Ambion, Inc.
Presenting Author: Stephanie Brooking, Ambion Europe Ltd - UK

P04048 - Detection of CD11b by High-throughput Fluorometric Microvolume Assay Technology using FMAT® System
Scott Cribbes,
Applied Biosystems
Nick Cox, Kirsty Rich and Martin Coldwell,
AstraZeneca R&D Charnwood
Presenting Author: Scott Cribbes, Applied Biosystems - United Kingdom

P04049 - Measurement of Heterotrimeric G-protein and RGS Interactions by a Novel Homogeneous TR-LRET Assay
Wayne Leifert, Kelly Bailey, Tamara Cooper, Amanda Aloia, Richard Glatz and Edward McMurchie,
CSIRO Molecular and Health Technologies.
Presenting Author: Wayne Leifert, CSIRO - Australia

P04050 - A Novel Array Format for Miniaturized Parallel Chemical Synthesis and In-situ Cell Based Screening
Varsha Gupte, Ulrike Beutling and Ronald Frank,
GBF - Gesellschaft für Biotechnologische Forschung mbH
Presenting Author: Varsha Gupte, GBF - Gesellschaft für Biotechnologische Forschung mbH - Germany

P04051 - Nickel Chelate Affinity Immobilization in Protein Interaction Assays: A Comparison of Alphascreen versus DELFIA.
E. Michael August, Leslie Martin, Martine Brault, Peter White, Cynthia Sledziona, Efren Romero and Carol A. Homon,
Boehringer Ingelheim Pharmaceuticals, Inc.
Presenting Author: Michael August, Boehringer Ingelheim Pharmaceuticals - US

P04052 - Development of a Mechanism-Based High-Throughput Assay for Human Liver Glycogen Phosphorylase a for the Identification of Glucose-Sensitive Inhibitors
Jennifer P. Gale, Sharine Wittkopp, Hu Li, David Tew, Thomas D. Meek, Sara H. Thrall and Mehul P. Patel,
GlaxoSmithKline
Presenting Author: Jennifer Gale, GlaxoSmithKline - USA

P04053 - Microfluidics Based Assays to Discover New Phosphatase Scaffolds
Christèle Frémaux, Dominique Besson, Dominique Perrin and Alexander Scheer,
Serono Pharmaceutical Research Institute
Presenting Author: Christèle Fremaux, Serono - Switzerland

P04054 - KingFisher - A Multifunctional Tool for Proteomics
Merja Mehto, Maija Partanen, Virpi Kymäläinen and Arja Lamberg,
Thermo Electron
Presenting Author: Merja Mehto, Thermo Electron - Finland

P04055 - A Study of Enteropathogenic Campylobacter in Diarrheal Patients at Alzahra Hospital in Isfahan, Iran
Seyed Asghar Havaei, Seyed Rasool Salehi, Mohammad Bokaian (Zahedan Univeristy), Seyed Ali Fazeli,
Isfahan University of Medical Sciences
Presenting Author: Seyed Asghar Havaei, universtiy - Iran

P04056 - Non-Specific Inhibitors - Identification of False Positives using High Througput Flow Particle Characterization
Joseph Goodwin, Michael Ardiff, Tim Ciolkosz and Michael Sha,
BD Biosciences
Presenting Author: Joseph Goodwin, BD Biosciences - USA

P04057 - A HTS for Inhibitors of DNA Non-homologous End-joining
Louise Bisset, Les Hanakahi (John Hopkins University), Stephen West (CR UK Clare Hall Laboratories) and Tim Hammonds,
Cancer Research Technology Development Laboratory
Presenting Author: Louise Bisset, Cancer Research Technology, Ltd. - London

P04058 - Development and Implementation of a HTS Assay for Inducers of the Excitatory Amino Acid Transporter-2 (EAAT-2)
Gary A. Piazza, E. Lucile White, Blossom Y. Sneed, Nicole Kushner, Joyce E. Harwell, Angela Y. Jones, Kristen Southworth, Lynn Rasmussen, Sara Cooley, Melinda I. Sosa, Anna Manouvakova, Thomas M. Fletcher III, Joseph A. Maddry, Subramaniam Ananthan, Jill Heemskerk and Jeffrey D. Rothstein,
Southern Research Institute, National Institutes of Health-National Institute of Neurological Disorders and Stroke (NIH-NINDS), and Johns Hopkins University
Presenting Author: Gary Piazza, Southern Research Institute - USA

P04059 - A Multiplex Assay Approach to Screening Cytoactive Compounds for Cell Cycle Disruption and Apoptotic Activity on the Guava EasyCyte, a Microplate-based Single Cell Analysis System
Amedeo Cappione and Katherine Gillis,
Guava Technologies, Inc.
Presenting Author: Amedeo Cappione, Guava Tachnologies, Inc. - USA

P04060 - The BIND Biosensor™ Technology : Label-free Detection for Small Molecule Binding
Peter Lowe, John Gerstenmaier, Lance Laing, Peter Fekkes,
SRU Biosystems
Presenting Author: Peter Lowe, SRU Biosystems - USA

P05001 - 3-Dimensional Multicoaxial Human Liver Bioreactor Design for Long-term Toxicity and Metabolism Studies
Nathaniel Hentz, Megan A. Christie, Karen M. Young, Mark B. Johnston, John W. Ludlow (Vesta Therapeutics), Sonya O. Meheux (Vesta Therapeutics), Christopher Seagle (UNC), Jason Winnike (UNC), and Jeff Macdonald (UNC),
ADMET Technologies
Presenting Author: Nathaniel Hentz, ADMET Technologies - US

P05002 - A Novel Plate-based Method for Measuring Plasma Protein Binding
Michael Shanler, Andre Dandeneau, Maria-Dawn Lilly, Joe Goodwin, Lucien Tarabelsi and Maurice Kashdan,
BD Biosciences
Presenting Author: Michael Shanler, BD Biosciences - USA

P05003 - Transcreener UGT Assay: Optimization for Commercial Enzyme Preparations and Poor Substrates
John Majer, Matt Staeben, Karen Kleman-Leyer, Tony Klink, Jennifer Fronczak, Thane Westermeyer and Robert G. Lowery,
BellBrook Labs
Presenting Author: John Majer, BellBrook Labs - USA

P05005 - Development of a Kinetic High Content Assay for Oxidative Stress
Vivek C. Abraham and Jeffrey R. Haskins,
Cellomics, Inc.
Presenting Author: Vivek Abraham, Cellomics - U.S.A.

P05006 - A Radiometric P450 Inhibition Screening Assay using PEI Coated YSi Scintillation Proximity Beads
Gerd Erhard,
GE Healthcare/Amersham Biosciences,
Marti Topcu, Achim Sauer and Thomas Arnhold,
Boehringer Ingelheim Pharma GmbH & Co. KG
Presenting Author: Gerd Erhard, GE Healthcare - Germany

P05007 - Ultra High Speed Automated In-Vitro Micronucleus Analysis
Geert Kalusche, Lynne Smith and Nick Thomas,
GE Healthcare
Presenting Author: Geert Kalusche, GE Healthcare - UK

P05009 - Kinase Directed ADME Platform
Matthias Baumann, Lars Neumann, Alexander Backes, Regina Gimple, Maria Koch, Miriam Richter-Roth and Monika Morbitzer,
GPC Biotech AG
Eddi Hoppe, Friedrich Kraetzer, Achim Freisleben, Birgit Felden and Manuela Gerhofer,
Axxima Pharmaceuticals AG
Presenting Author: Severine Dedier, GPC Biotech AG - Germany

P05010 - Monitoring Early Compound Liabilities Using HCS Techniques
Ann F. Hoffman, Shannon Hamilton, Theresa Truitt and Ralph J. Garippa,
Hoffmann-La Roche Inc.
Presenting Author: Ann Hoffman, Hoffmann-La Roche Inc. - USA

P05011 - Identification of PepT1 Substrates and Inhibitors using a Novel Tool for Ion Transporter Research
Bela Kelety, Natalie Watzke, Wolfgang Dörner, Kerstin Diekert, Renate Gauß and Petr Obrdlik,
IonGate Biosciences GmbH
Presenting Author: Bela Kelety, IonGate Biosciences - Germany

P05012 - Automation for Drug Transport Assay using 96-well Caco-2 Filter Plate
L. Fossati, E. Hardillier, F. Guillet, S. Moissenet and N. Maubon,
Laboratoire Fournier,
G. Wasselin and C. Lesturgeon,
Caliper Life Sciences,
V. Marcheville,
Millipore
Presenting Author: Nathalie Maubon, Laboratoires Fournier Pharma - France

P05013 - Automation for CYP Inhibition Assay
L. Fossati, N. Chameroy, A. Flageolet, R. Dechaume and N. Maubon,
Laboratoires Fournier,
G. Wasselin and C. Lesturgeon,
Caliper Life Sciences
Presenting Author: Nathalie Maubon, Laboratoires Fournier Pharma - France

P05014 - Automation for Metabolic Stability Assay
A. Flageolet, L. Fossati, E. Hardillier, F. Guillet, D. Chevillon and N. Maubon,
Laboratoires Fournier,
G. Wasselin,
Caliper Life Sciences
Presenting Author: Nathalie Maubon, Laboratoires Fournier Pharma - France

P05015 - Towards an Industry Consensus on Caco-2 Permeability Measurement
Keith Anderson and Ross Hawkins (NIBSC), LGC
Presenting Author: Keith Anderson, LGC - UK

P05016 - Advances in Transport Receiver Plate Capabilities
Greg Kazan and Marcy Engelstein,
Millipore Corporation
Presenting Author: Gregory Kazan, Millipore Corporation - USA

P05017 - Early Detection of Cardiotoxic Side Effects in the Drug Development Process
Thomas Meyer,
Multi Channel Systems
Kathrin Henes, and Elke Günther,
Natural and Medical Sciences Institute at the Tübingen University
Presenting Author: Thomas Meyer, Multi Channel Systems MCS GmbH - Reutlingen

P05018 - In vitro Safety Pharmacology Profiling at Novartis: Implementation and First Lessons
Jacques Hamon, Kamal Azzaoui, Helene Le Coq, Tiffany Luethi, Sabrina Staub, Pernilla Lervik, Solange Vidal, Bernard Faller, Steven Whitebread, Joe Chin, Alex Fekete, Emily Woolverton,
Novartis
Presenting Author: Jacques Hamon, Novartis - Switzerland

P05019 - Utilization of the ATPlite 1step Detection System for Homogenous Automated Cytotoxicity Assays
Hanh Le, Harry Harney, Steve Hurt, Robert Stanaker, Chantal Illy, and Rajesh Manchanda,
PerkinElmer Life and Analytical Sciences
Presenting Author: Hanh Le, PerkinElmer LAS - USA

P05020 - Incorporation of an Oxidative Stress Biomarker into High Content Screening (HCS) for Human Toxicity Potential
Gareth W. Phillips (Pfizer/Cellomics), William A. Irwin (Cerep), Elodie J. Howard-Cofield (Cerep), Laura E. Randle (University of Liverpool), Vivek C. Abraham (Cellomics), Jeffrey R. Haskins (Cellomics) and Peter J. O'Brien,
Pfizer
Presenting Author: Gareth Phillips, Pfizer - UK

P05021 - Ultra-High-Throughput Profiling of Compounds using Luminescent Assays and the Aurora® Discovery BioRAPTR FRD™ Workstation
John Watson, Brad Larson, Tracy Worzella, and Mark Chong (Aurora Discovery),
Promega Corporation
Presenting Author: John Watson, Promega Corporation - US

P05022 - High-Throughput Compound Profiling Using Promega Luminescent Assays on a Tecan Freedom Evo 200 System
Tracy Worzella, Brad Larson, John Watson and Siegfried Sasshofer (Tecan),
Promega Corporation
Presenting Author: Tracy Worzella, Promega Corporation - USA

P05023 - Automating Cytochrome P450 Screening Using Promega P450-Glo CYP450 Assays and the Protedyne BioCube System
Michael Catalano, Tracy Worzella (Promega Corp.), Daniel Kephart (Promega Corp.), Arlene Silviera (Promega Corp.), Jason Quarles, Lorah Perlee, Ralph Ito,
Protedyne Corp.
Presenting Author: Michael Catalano, Protedyne Corp. - USA

P05024 - LeadStream Performance Characteristics over Hundreds of Compounds and Multiple Assays
Robert DeWitte, Marta Kozak, Andreas Stelzer, Robert Dunn-Dufault, Hansjoerg Haas (Thermo Electron Corp), Lance Heinle, Russel Robins,
Pfizer, Inc.
Presenting Author: Robert DeWitte, Thermo Electron Corporation - Canada

P05025 - High Throughput Drug-drug Interaction Assay: Comparison of LeadStream with a Semi-automated Approach
Robert Dunn-Dufault, Marta Kozak, Andreas Stelzer, Robert DeWitte, Hansjoerg Haas (Thermo Electron Corp.), Lance Heinle, Russel Robins and Kyle Lovan ,
Pfizer, Inc.
Presenting Author: Kyle Lovan, Thermo Electron Corporation - Canada

P05027 - High Throughput Metabolic Stability Assay: Comparison of LeadStream with a Aemi-automated Approach
Andreas Stelzer, Marta Kozak, Robert Dunn-Dufault, Robert S. DeWitte, Hansjoerg Haas (Thermo Electron Corp.), Lance Heinle, Russel Robins,
Pfizer, Inc.
Presenting Author: Hansjoerg Haas, Thermo Electron Corporation - Canada

P05028 - Screening of Protein - Protein Interactions
Martinus Capelle, Robert Gurny and Tudor Arvinte,
University of Geneva
Presenting Author: Martinus Capelle, University of Geneva - Switzerland

P05029 - An Automated High Throughput UPLC/MS/MS Protocol with Multi-Mode Ionization for In-vitro Metabolic Stability Test
Kate Yu, Peter Alden, Rob Plumb, Li Di, Susan Li and Edward Kerns (Wyeth Research),
Waters Corporation
Presenting Author: Kate Yu, Waters Corporation - USA

P05030 - An Improved High-Throughput Approach for the Free Fraction of Drug Candidates Strongly Bound to Plasma Proteins
Joachim Schuhmacher (Bayer Health Care), Joachim Nöller, Johannes Schmitt and Thorsten Hartmann,
NIMBUS Biotechnology
Presenting Author: Joachim Nöller, NIMBUS Biotechnology - Germany

P05031 - Rapid Analysis of 7-Hydroxycoumarin Glucuronide Using Micro Parallel Liquid Chromatrography
Kevin Crellin, Paren Patel,
Nanostream
Presenting Author: Kevin Crellin, Nanostream - USA

P05032 - A Fully Automated Workstation for Testing Flow-Based Kinetic Solubility of Compounds
Maria-Dawn Lilly, Michael Shanler, Michael Ardiff, Maurice Kashdan, Christine Aubin and Joseph Goodwin,
BD Biosciences
Presenting Author: Maria Dawn Lilly, BD Biosciences - USA

P05034 - Development of an In Vitro Metabolic Stability Screening Assay using an Incubation Platform Operated by a LabView Interface in Combination with an Automated LC-MS/MS Analysis System
Thomas Arnhold, Andreas Luippold, Wolfgang Joerg, Ralf Lotz, and Achim Sauer,
Boehringer Ingelheim Pharma GmbH & Co. KG
Presenting Author: Thomas Arnhold, Boehringer Ingelheim Pharma GmbH & Co. KG - Germany

P05035 - Unexpected Compound Effects on Cell Physiology Detected by a New In Vitro Analyzing System
Ralf Ehret, Axel Kob, Heiko Holst, Andreas Keuer, Sabine Drechsler, Ricarda Niendorf, Elke Thedinga, Werner Baumann (Universität Rostock), Ingo Freund (Micronas GmbH) and Mirko Lehmann (Micronas GmbH),
Bionas GmbH
Presenting Author: Ralf Ehret, Bionas GmbH - Germany

P05036 - Leveraging the Power of High Content Screening for Monitoring Oxidative Stress
Chandrasekaran Vasudevan and Jeffery R Haskins,
Cellomics, Inc.
Presenting Author: Chandrasekaran Vasudevan, Cellomics Inc. - USA

P05037 - MAO-Glo™ Assay: Fast and Easy Luminescent Assay to Measure Monoamine Oxidases
Terry Riss, M. Valley, W. Zhou (Promega Biosciences Inc.), E. Hawkins, J. Shultz, T. Good (Promega Biosciences Inc.), D. Good (Promega Biosciences Inc.) and K.V. Wood,
Promega Corporation
Presenting Author: Terry Riss, Promega Corporation - USA

P06002 - Maximizing the Identification of Leads from Compound Mixtures
Usha Warrior, Sujatha Gopalakrishnan, Linda Traphagen, Danli Towne, Gail Freiberg, Patrick Humphrey, James Kofron and David J. Burns,
Abbott Laboratories
Presenting Author: Usha Warrior, Abbott Laboratories - USA

P06003 - A General Platform for the Generation of Functional GPCR Assays for uHTS
Lia Scarabottolo, Sibilla Berni Canani, Silvia Bovolenta, Viviana Agus, Anna Della Bella, Giuliana Piazza, Maria Grazia Giribaldi and Stefan Lohmer,
Axxam
Presenting Author: Lia Scarabottolo, Axxam - Italy

P06004 - Optimized In Vitro Chemotaxis Assay for Monocytes and THP-1 Cells
Suparna Sanyal and Susan Qian,
BD Biosciences
Presenting Author: Suparna Sanyal, BD Bioscience - USA

P06005 - A Novel Homogeneous Calcium Assay Kit for Use in Probenecid Sensitive Assays
Steve Titus, Isabel Llorente, Bingfang Huan and Xiao Li,
BD Biosciences
Presenting Author: Bingfang Huan, BD Biosciences - USA

P06006 - Development of a Novel Homogeneous Calcium Assay Kit for Live Cell Analysis of G_s, G_q and G_i Coupled Receptors
Isabel Llorente, Jianming Lu, Steve Titus, and Xiao Li,
BD Biosciences
Presenting Author: Xiao Li, BD Biosciences - USA

P06007 - Targeting Hh and Wnt Pathways with Small Molecules
Sergey Bugrov and Alexander S. Kiselyov,
ChemDiv, Inc.
Presenting Author: Sergey Bugrov, ChemDiv, Inc. - USA

P06008 - A Fully Homogeneous Cell-based Assay for Monitoring the Conversion of Estrone (E1) into Estradiol (E2) by Human Breast Cancer Cells
Emmanuel J. Claret, Sandrine Cabirol and Patrick Seguin,
Cisbio international
Presenting Author: Emmanuel Claret, Cisbio international - France

P06009 - Introduction of a New HTRF® Acceptor. Development of a Complete GPCR Platform for a G_s, G_i and G_q Screening
Monique Amoravain, Stéphanie Lyotard, Ulf Bömer (Schering AG), Christian Bersdorf (Schering AG), Patrick Seguin, Jean-Luc Tardieu and Eric Trinquet,
Cisbio international
Presenting Author: Jean-Luc Tardieu, CISBIO INTERNATIONAL - FRANCE

P06010 - Performance Evaluation of a Minituarized Calcium Mobilization Assay on 384 Well Low Volume Microplates
Alice Gao,
Corning Incorporated
Presenting Author: Alice Gao, Corning Inc. - USA

P06011 - Development of a Microplate-Based Assay to Measure Intracellular Calcium in LLC-PK1 Cells, a Renal Epithelial Model
John Duke, Chantale Boisvert (Theratechnologies, Inc.) and Alice Gao,
Corning Incorporated
Presenting Author: John Duke, Corning Incorporated - USA

P06012 - A Homogeneous Assay to Monitor Nuclear Hormone Receptor Degradation using β Galactosidase Enzyme Fragment Complementation.
Joseph Horecka and Richard M. Eglen,
DiscoveRx Corp.
Presenting Author: Richard Eglen, DiscoveRx Corp - USA

P06013 - Comparison of the Functional HTRF cAMP Assay Technology to AlphaScreen cAMP Technology using Human 5HT-7 Receptor Transfected AV12 Cells
Todd R. Wiernicki, Renee A. Lynch and Christopher M. Moxham,
Eli Lilly and Company
Presenting Author: Christopher Moxham, Eli Lilly and Company - USA

P06014 - Development of an Enzyme Fragment Complementation Assay for Adenosine 3’5’ Cyclic Monophosphate (cAMP) and Its Validation for Sensitive Pharmacological Screening at G Protein-coupled Receptors (GPCRs)
Jeffrey Horton, Michael Looker, Elizabeth Price, Sarah Cox and Kelvin Hughes,
GE Healthcare
Presenting Author: Michael Looker, GE Healthcare - UK

P06015 - The Application of Frozen Cells in High Throughput Reporter Screens
Angela Dunne, Damon Finnigan, Matilde Caivano and Peter Morley,
GlaxoSmithKline
Presenting Author: Angela Dunne, GlaxoSmithKline - UK

P06016 - Data Analysis Algorithm Choice Affects Both Z' Factor and Hit Detection: A Case Study using FDSS6000
Shouming Du and Kelly Cassutt,
Hamamatsu Photonics Corporation,
M. Abousleimin and W. Tang,
Johnson and Johnson Pharmaceutical Research Department
Presenting Author: Shouming Du, Hamamatsu - US

P06017 - Fluorescent Drug Libraries Shed New Light On Assay Optimization
Pascal Villa, Marcel Hibert, Jean-Luc Galzi, Dominique Bonnet, Rana Dagher, Dagmar De Mey, Bruno Didier, Cara Fraley, Fabrice Guiller, Muriel Hachet-Haas, Jean-Paul Humbert, Marie-Claude Kilhoffer, Claude Philippe, Claire Pigault, Christel Pourbay, Didier Rognan, Christel Valencia and Jacques Haiech,
IFR85-University of Strasbourg
Presenting Author: Pascal Villa, IFR85-University of Strasbourg - FRANCE

P06018 - HTS Assays for Detection of AR, PR, GR, and PPARγ Modulators Utilizing Red and Far Red-Shifted Fluorescent Ligands
Bryan D. Marks, Steven R. Duff, Hildegard C. Eliason, James Farnham, Naveeda Qadir, David A. Lasky, Mohammed S. Shekhani and Kurt W. Vogel,
Invitrogen Corporation
Presenting Author: Bryan Marks, Invitrogen - USA

P06019 - A New No-wash Calcium Assay for HTS
Jeff Dzubay, Birte Schulenberg, Vladimir Martin, Randy Hoffman, Larry Greenfield, and Iain Johnson,
Invitrogen/Molecular Probes, Inc.
Presenting Author: Jeff Dzubay, Invitrogen/ Molecular Probes - USA

P06020 - Comparison of HTS Systems for Measuring Intracellular Calcium Levels
Jack Kauffman, Susan Yagel, Lori Westover, Hong Xin, Weimin Tang, Mojgan Abousleiman, Cailin Chen, Tasha Reitz, Mary Jo Wildey, and Matthew Todd,
J&J Pharmaceutical Research and Development, L.L.C.
Shouming Du and Kelly Cassutt,
Hamamatsu
Susan Murphy and Kelly Mathews,
Molecular Devices Corp.
Presenting Author: Jack Kauffman, J&J Pharmaceutical Research and Development, L.L.C. - USA

P06021 - Combining FLIPR and Transfluor: A Novel Assay for the Sequential Analysis of Calcium Flux and Receptor Desensitization.
P. Turpin, R. Loui, J. Quast, M. Kassinos, L. Gaudet, J. F. Liao, W. Chan, R. Sportsman, P. Rickert and M. Sjaastad,
Molecular Devices Corporation
Presenting Author: Michael D. Sjaastad, Molecular Devices Corporation - USA

P06022 - A New Screening Paradigm for Miniaturized Cellular Assays in 1536 Well Microtitre Plates using Aequorin Based Assays and the New Ultra High Throughput Screening Platform, LumiLux™
Pavan Sanotra, Sofia Vikstrom, Craig Malcolm, Janet Park and Claire Hooper,
PerkinElmer Life and Analytical Sciences
Presenting Author: Pavan Sanotra, PerkinElmer - UK

P06023 - LANCE™ cAMP - A uHTS cAMP Detection Assay for Use With Membranes
Patricia Kasila, Hao Xie,
PerkinElmer Life and Analytical Sciences
Presenting Author: Patricia Kasila, PerkinElmer Life and Analytical Sciences - USA

P06024 - A Comprehensive Comparison of State of the Art cAMP Assays
Patricia Kasila and Hao Xie,
PerkinElmer Life and Analytical Sciences
Presenting Author: Achim Von Leoprechting, PerkinElmer Life and Analytical Sciences - USA

P06025 - A Novel Analysis Method for FLIPR Data for Identifying Compound Artifacts and Predicting 'Attractive' Compounds
Philip Gribbon, Chris Chambers, Andreas Sewing (Pfizer, Inc.) and Kaupo Palo,
Evotec Technologies GmbH
Presenting Author: Philip Gribbon, Pfizer - UK

P06026 - Generation of a Stable and Robust Functional Assay for mGluR2, 5 and 8 Ligands using an Ecdysone-inducible System
Gianluca Lozza, Roberta Petrò, Enrica Diodato, Patrick M. Downey, Mariagrazia Grilli and Angelo Reggiani,
Schering-Plough Research Institute
Presenting Author: Gianluca Lozza, Schering-Plough Research Institute - Italy

P06027 - The High Throughput Screening of Melanocortin 4 Receptor Ligands from Korean Herbal Plant Extracts and Frog Peptides
Ernest U. Do, Eun Bae Jo, Su-il Kim and Bong-Jin Lee,
Seoul National University,
Long Zhu Piao and Jaekyoon Shin,
Sungkyunkwan University
Presenting Author: Ernest Do, Seoul National University - Republic of Korea

P06028 - Ca⁺⁺ Triggered Photina™ Luminescence Measurements on GENios Pro™
Mateja Niederreiter, Manfred Lansing and Sabrina Corazza (Axxam Srl),
Tecan Austria GmbH
Presenting Author: Mateja Niederreiter, Tecan Austria GmbH - Salzburg Land

P06029 - High Throughput Homogeneous Cell-Based Assays of ERK Activation: A GPCR Discovery Platform to Replace Ca²⁺
Michael F. Crouch, Ron I.W. Osmond, Antony J. Sheehan and Anthony R. Dyer,
TGR BioSciences
Presenting Author: Michael Crouch, TGR BioSciences - Australia

P06030 - Detecting the FRET Response of the GeneBLAzer® Cell Line D1 CRE-bla CHO.K1 to Agonists and Antagonists using the Acumen Explorer 405
Christopher Lupton, Paul Wylie (TTP LabTech Ltd) and Randy Hoffman,
Invitrogen Corporation
Presenting Author: Paul Wylie, TTP LabTech Limited - UK

P06032 - Can Orthogonal Technologies Reduce False Positives in GPCR Primary Screening
W. Tang, M. Abousleimin, D. Colone, and M. J. Wildey,
Johnson and Johnson Pharmaceutical Research Department, Raritan,
Shouming Du and Kelly Cassutt,
Hamamatsu Photonics Corporation
Presenting Author: Weimin Tang, Johnson and Johnson - USA

P06033 - A Comparison of cAMP Cell-based Detection Technologies
Mark Slack, Andreas F Kahrs Evotec
Presenting Author: Mark Slack, Evotec - Germany

P06034 - Multiplexing Nonadherent Cells Loaded Using One of Two Calcium Indicator Dyes: Effect on Calcium Mobilization Detection and Analysis Using the FDSS6000
Masanobu Fujiwara, Al McGrath, Shouming Du, Kelly Cassutt (Hamamatsu Corporation) and Mojgan Abousleimin, Weimin Tang, and Dean Colone,
Johnson and Johnson Pharmaceutical Research Department
Presenting Author: Masanobu Fujiwara, Hamamatsu Corporation - USA

P06035 - Discovery of Selective S1P/ LPA Receptor Ligands in Drug Screening via a G_i- or G_q-dependent Calcium Assay
Sandra Siehler, Rochdi Bouhelal and Danilo Guerini,
Novartis Institutes for BioMedical Research
Presenting Author: Sandra Siehler, Novartis Institutes for BioMedical Research - Switzerland

P06036 - Evaluation of Fluorescence Polarization Assays for Nuclear Receptors using Ligands Labeled with Two Different Fluormones
Fanyi Jiang and Nan Albertson,
AstraZeneca
Presenting Author: Fanyi Jiang, AstraZeneca - Sweden

P06037 - Evaluation of IP-One, a new HTRF® Assay to Monitor G_q Coupled GPCR Response. Comparison with FLIPR under HTS Conditions
Fumiyo Tozawa-Takahashi, Yoshikazu Tanaka, Kimiko Nishida, Shuichiro Inagaki, Jean-Luc Tardieu (Cisbio international), Sylvie Sulocha (Cisbio international), Kazuki Sato (Nihon Schering K.K) and Hiroshi Takemoto,
SHIONOGI & CO. LTD.
Presenting Author: Tardieu Jean-Luc, Cisbio - France

P06038 - Development of a Simple ELISA Format Assay to Screen Potential Ligands against Nuclear Hormone Receptors
Akira Okuyama, Hatano Yasuhiko, Haruki Mizukami and Jun Yanagisawa (University of Tsukuba),
EnBioTec Lboratories Co., Ltd.
Presenting Author: Akira Okuyama, EnBioTec Laboratories Co., Ltd. - Japan

P06039 - FLIPR^TETRA_™ and Aequorin Based Luminescence Assays: IB-MECA Stimulated Calcium Mobilization in CHO-K1 Cells Expressing Adenosine A₃ Receptor
Jennifer McKie Carole Crittenden and Paolo Meoni (Euroscreen, SA),
Molecular Devices, Corp.
Presenting Author: Jennifer McKie, Molecular Devices Corp. - USA

P06040 - Evaluation of New cAMP HTRF Kits
Pierre-Eloi Imbert, Monique Amoravain (Cisbio International), Christian Parker and Daniela Gabriel,
Novartis Institutes for Biomedical Research
Presenting Author: Pierre-Eloi Imbert, Novartis Institutes for Biomedical Research - SWITZERLAND

P06041 - ERK Phosphorylation: A Multi-card Signal to Study the Pharmacology of Small Molecules Modulating GPCR Activated Pathways
Didier Leroy, Caroline Waltzinger, Yves Humbert, Marc Missotten, Thierry Martin, Bernard Françon, Anthony Nichols, Paul Lang and Alexander Scheer,
Serono Pharmaceutical Research Institute
Presenting Author: Didier LEROY, SERONO - Switzerland

P06042 - Plate-based Label-Free Screening of Small Molecules: Direct Binding, Agonism and Antagonism of Coactivator Binding to a Nuclear Receptor
Lance Laing, Peter Lowe, John Gerstenmaier and Julio Martin (Glaxo SmithKline),
SRU Biosystems
Presenting Author: Lance Laing, SRU Biosystems - USA

P06043 - A Homogeneous Assay to Monitor Cellular Mitosis using β-Galactosidase Complementation
P.A.Fung, K.R. Olson and R. M Eglen,
DiscoveRx Corporation
Presenting Author: Richard Eglen, DiscoveRx - USA

P06044 - Monitoring Translocation Activity of Transcription Factors and Nuclear Hormone Receptors Using Enzyme Fragment Complementation (EFC)
P.A.Fung, K. Peng, B.L. Bosano, P. Kobel, K.R. Olson and R. M. Eglen,
DiscoveRx Corporation
Presenting Author: Richard Eglen, DiscoveRx - USA

P07001 - Identification of a New Class of PGT Inhibitors and Characterization of Their Biological Effects on PGE2 Transport
Yuling Chi, Sonya Khersonsky (New York University), Young-Tae Chang (New York University) and Victor Schuster,
Albert Einstein College of Medicine
Presenting Author: Yuling Chi, Albert Einstein College of Medicine - USA

P07002 - Fluorimetric Detection of Matrix Metalloproteinases Using FAM-Peptide-QXL 520 Substrates
Yi Tang, April Huang, Kabun Ichihara, Anita Hong and Zhenjun Diwu,
AnaSpec, Inc.
Presenting Author: Zhenjun Diwu, AnaSpec, Inc. - USA

P07003 - A Sensitive and Scalable Fluorimetric Assay for Detection and Screening of Hepatitis C Virus Protease
Yi Tang, Junge Lu, Ling Sheng, Xiaohe Tong, Anita Hong and Zhenjun Diwu,
AnaSpec, Inc.
Presenting Author: Anita Hong, AnaSpec, Inc. - USA

P07004 - Validation of IonWorksHT as a Medium-throughput Electrophysiology Assay for hERG Activity
M.H. Bridgland-Taylor, A.C. Hargreaves, A. Easter, A. Orme, A. Harmer, D.C. Henthorn, A. Davis, B.G. Small, C.G. Heapy, F. Paulsson, I. Jacobson, T.G. Hammond, M. Sullivan, E. Sullivan, J-P. Valentin, and C.E. Pollard, K. Schroeder (Essen Instruments) and B. Neagle (Essen Instruments),
AstraZeneca
Presenting Author: Matt Bridgland-Taylor, AstraZeneca - England

P07005 - Cell-based Rubidium Flux Assay for HTS of Kv1.3 Channel
Sikander Gill, Rajwant Gill, David Wicks, and Dong Liang,
Aurora Biomed Inc.
Presenting Author: Sikander Gill, Aurora Biomed Inc - Canada

P07006 - Establishment of Cell-free Electrophysiology for Ion Transporters
Henning Vollert, Sven Geibel and Thomas Licher,
Aventis Pharma
Presenting Author: Henning Vollert, Aventis Pharma - Germany

P07007 - Photina™: A New Tool for Detection of Ca⁺⁺ Signalling in High Throughput Screening
Lia Scarabottolo, Silvia Bovolenta, Giorgia Michela Stucchi, Viviana Agus, Sibilla Berni Canani and Sabrina Corazza,
Axxam
Presenting Author: Sabrina Corazza, Axxam - Italy

P07008 - Cell Based Ultra High Throughput Screening: Insight Into the Hit Identification Process
Elisabeth Pook, Eckhard Bender and Bernd Kalthof,
Bayer HealthCare AG
Presenting Author: Elisabeth Pook, BAYER HealthCare - Germany

P07009 - Ion Channel Screening: The Impact of New Technologies and Targeted Libraries
Adrian Kinkaid, Martin Slater, Richard Hill, John Harris and Joelle Le,
BioFocus Discovery Ltd.
Presenting Author: Adrian Kinkaid, BioFocus Discovery Ltd - United Kingdom

P07010 - New Advances in Patch-Clamp-Based Ion Channel Screening
Mattias Karlsson, Cecilia Farre, Jon Sinclair (Chalmers Technical University) , Owe Orwar (Chalmers Technical University),
Cellectricon
Presenting Author: Mattias Karlsson, Cellectricon - Sweden

P07011 - Uncertainty Principle in HTS: Do We Target the Right Target?
Ilya Okun, Alexander Khvat, Sergey Tkachenko, Volodymyr Kysil, Sergey Maliartchouk and Alexandre Ivachtchenko,
ChemDiv, Inc.
Presenting Author: Ilya Okun, ChemDiv, Inc. - USA

P07012 - Analysis and Optimization of Functional Ion Channel Expression in Recombinant Cell Lines using the IonWorks HT Electrophysiology Platform
Andrew Powell, Jane Luck, Yu Hua Chen, Mark Chen, Jenni Cryan, Sandra Arpino, Tim Dale, David Downie, Helen Meadows, Jeff Clare and Derek Trezise,
GlaxoSmithKline R&D
Presenting Author: Andrew Powell, GlaxoSmithKline R&D - UK

P07013 - Cell Plate Mixing versus Pipet Mixing: A Comparative Study on Reducing DMSO Artifacts and Improving Assay Performance Using the FDSS6000
Kelly Cassutt,
Hamamatsu Corporation,
Mojgan Abousleiman and Weimin Tang,
Johnson and Johnson Pharmaceutical Research Department
Presenting Author: Kelly Cassutt, Hamamatsu Corporation - USA

P07014 - Counterscreening Early in Lead Discovery as an Effective Method in the Identification of an Anthrax Lethal Factor Metalloprotease Inhibitor with High Selectivity Compared to Host Proteases
Sherri Millis,
Hawaii Biotech, Inc.
Presenting Author: Sherri Millis, Hawaii Biotech, Inc. - USA

P07015 - High-throughput Screening for N-type Calcium Channel Blockers Using a Scintillation Proximity Assay
Sui-Po Zhang, Jack Kauffman, Susan Yagel and Ellen Codd,
Johnson & Johnson Pharmaceutical Research and Development. L.L.C
Presenting Author: Sui-Po Zhang, Johnson & Johnson Pharmaceutical Research and Development, L.L.C. - USA

P07016 - Development of a FDSS6000-based High-Throughput Screening (HTS) Assay for T-type Ca²⁺ Channels
Yoonjee Kim, Seonhee Seo and Hyewhon Rhim,
Korea Institute of Science and Technology
Presenting Author: Hyewhon Rhim, Korea Institute of Science and Technology (KIST) - Korea

P07017 - A Novel Peptide Substrate for New Protease Assays
Jiyan Chen, Xinzhan Peng, William Volcheck, Garrick Little, Xinshe Xu, Chuck Prescott and Daniel Draney,
LI-COR Biosciences
Presenting Author: Jiyan Chen, Li-Cor BioSciences - USA

P07018 - A Near-Infrared Fluorescent Protease Activity Assay and Substrate
Harry Osterman, Jiyan Chen, Xinzhan Peng, Chuck Prescott, William Volcheck, Xinshe Xu, Garrick Little, and Daniel Draney,
LI-COR Biosciences
Presenting Author: Harry Osterman, LI-COR Biosciences - USA

P07019 - Multiplex Detection of Alzheimer's Disease-related Proteins and Peptides
Sharon H. Tynan, Patrick Keller, Jennifer Lewis, Robert M. Umek, Jacob N. Wohlstadter,
Meso Scale Discovery
Presenting Author: Sharon Tynan, Meso Scale Discovery - USA

P07020 - Intracellular Caspase-3 Assays using Cell-permeant Fluorogenic Substrates
Iain Johnson,
Molecular Probes Invitrogen Detection Technologies
Presenting Author: Iain Johnson, Molecular Probes Invitrogen Detection Technologies - USA

P07021 - Running Hit-to-lead Route in the Field of HIV-1 Protease Dimerization Inhibitors
Vladimir Sulimov and Olga Kondakova,
Moscow State University
Alexey Romanov, Alexey Chernobrovkin, Sofia Luschekina, Yuriy Ivanov, Andrey Lisitsa and Alexander Archakov,
Institute of Biomedical Chemistry RAMS
Sergey Zhabin,
General Physics Institute RAS
Paul Lewi,
Janssen Pharmaceutical NV
Presenting Author: Vladimir Sulimov, Moscow State University - Russia

P07022 - Ligand and Voltage Gated Ion Channel Recording with the Roboocyte
Christine Leisgen, Ulrich Pehl (Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen) and Elke Guenther (Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen),
Multi Channel Systems MCS GmbH
Presenting Author: Christine Leisgen, Multi Channel Systems MCS GmbH - Germany

P07023 - Development of Voltage Sensor Probes Assays for Cardiac Potassium Ion Channel Cell Lines using a Prototype CellLux Platform
Soo-Hang Wong, Julie Guimond (Montreal Heart Institute), Genevieve Hamann, Genevieve Pinard, Terence Hébert (Montreal Heart Institute), Dean Wenham and Jarkko Karvinen,
PerkinElmer Life and Analytical Sciences
Presenting Author: Jarkko Karvinen, PerkinElmer - Canada

P07024 - hERG Binding Assays for the Identification of Potentially Cardiotoxic Compounds
Lucille Beaudet, Nathalie Bouchard, Genevieve Hamann, Soo-Hang Wong, David Rivard, Terence E. Hebert (Montreal Heart Institute), Julie Guimond (Montreal Heart Institute) and Dean Wenham,
PerkinElmer Life and Analytical Sciences
Presenting Author: Lucille Beaudet, PerkinElmer Life and Analytical Sciences - Canada

P07025 - High Level Performance in Cell Based Assays using CellLux™, A Versatile Cellular Imaging Drug Discovery Platform
Craig Malcolm, Pavan Sanotra, Janet Park and Claire Hooper,
PerkinElmer Ltd.
Presenting Author: Craig Malcolm, PerkinElmer Ltd. - United Kingdom

P07026 - Rapid ICE™ - Rapid Ion Channel Electrophysiology
Claire Quinn, Kirsty Macfarlane and Alison Templeton,
Quintiles Limited
Presenting Author: Claire Quinn, Quintiles Ltd - United Kingdom

P07027 - DiscoveryDot, A Nanoliter Microarray for Drug Screening
Haiching Ma, Kurumi Y. Horiuchi, Yuan Wang, Stefan A. Kucharewicz and Scott L. Diamond (University of Pennsylvania),
Reaction Biology Corp.
Presenting Author: Haiching Ma, Reaction Biology Corp. - USA

P07028 - Automatic Analysis of FLIPR Based Ion Channel Screens with ActivityBase (IDBS)
Hendrick Bothmann, Letizia Magnoni, Silvia Papini, Andreas Kremer, Wolfgang Fecke and Georg C. Terstappen,
Sienabiotech S.p.A.
Presenting Author: Hendrick Bothmann, Sienabiotech S.p.A. - Italy

P07029 - A BACE1 TR-FRET Assay for the Analysis of Enzyme Inhibition Mechanisms
Valentina Porcari, Elena Pilli, Georg C. Terstappen and Wolfgang Fecke,
Sienabiotech S.p.A.
Presenting Author: Valentina Porcari, Sienabiotech S.p.A. - Italy

P07030 - Application of QPatch 16 for Drug Screening of Ligand-gated Ion Channels
Nicoline R. Andersen, Simon Pedersen, Jeppe K. Christensen, Michael Stoltenborg, Morten Sunesen, Jonatan Kutchinsky and Niels J. Willumsen,
Sophion Bioscience
Presenting Author: Niels J. Willumsen, Sophion Bioscience A/S - Denmark

P07031 - Development of a FDSS6000-based High-throughput Screening (HTS) Assay for T-type Ca²⁺ Channels
Yoonjee Kim, Seonhee Seo, Dongjin Kim and Hyewhon Rhim,
Korea Institute of Science and Technology
Presenting Author: Hyewhon Rhim, Korea Institute of Science and Technology (KIST) - Korea

P07032 - IonWorks Compound Screening against Cardiac Sodium Channels in a Native Cell Line
Qiang Lu, Howard Zhang, Ru Shen, Lan He, Mark Bowlby and John Dunlop,
Wyeth Research
Presenting Author: Qiang Lu, Wyeth Research - USA

P07033 - FLIPR Assay for GABA_A Channel Function
Tongming Chen, Tyrell Norris, Carolann Thompson, Michael Wood, David Gurley, Robert Bostwick and Jay Liu,
AstraZeneca
Presenting Author: Tongming Chen, ASTRAZENECA - USA

P07034 - Analysis of hERG Subunit Composition Impact On Binding Assays
Vincent Dupriez and Patricia Buchlin,
Euroscreen s.a.
Presenting Author: Vincent Dupriez, Euroscreen - Belgium

P07035 - Live Cell Interrogation of Hypoxia-induced Signaling
Jared Browning, Kun Bi, John Printen (Invitrogen) and Menghang Xia, Jeremy Allred and James Inglese,
NIH Chemical Genomics Center
Presenting Author: Jared Browning, Invitrogen - USA

P07036 - Comparison of a hERG Binding Assay with Automated Patch Clamp using the PatchXpress 7000A
Nathan J. Lautermilch, Adam S. Bishop, Karen F. Marcoe, Sidney Bounds, Chun-Hsiung Lin, Jin-Jye Feng, Atsui Lin, Fong-Chi Cheng, Richard Mitchel, Peter J.S. Chiu and James W. Baumgartner,
MDS Pharma Services
Presenting Author: Nathan Lautermilch, MDS PS - USA

P08001 - Consequences of Choosing a Model Substrate for HTS
Leonard J. Blackwell, Dwayne Allen, Ioana Popa-Burke, Carla Suto, Nick Hodge, and Bill Janzen,
Amphora Discovery
Presenting Author: Leonard Blackwell, Amphora Discovery - USA

P08002 - Kinase Pathway Screening Using High Throughput Microfluidics
Leonard J. Blackwell, Ioana Popa-Burke, Carla Suto, Nick Hodge, and Bill Janzen,
Amphora Discovery
Presenting Author: Leonard Blackwell, Amphora Discovery - USA

P08003 - Simplifying Kinase Profiling using ADP Detection with the Transcreener Kinase Assay
Karen M. Kleman-Leyer, Tony A. Klink, Thane A. Westermeyer and Robert G. Lowery,
BellBrook Labs
Presenting Author: Karen Kleman-Leyer, BellBrook Labs - USA

P08004 - Interactions of Drug Candidates with Protein Phosphatases and Kinases using Label Free Protein Interaction Analysis
Olof Karlsson, Peter Stenlund, Åsa Frostell-Karlsson, Robert Karlsson, Maria Jungnelius and Helena Nordin,
Biacore AB
Presenting Author: Olof Karlsson, Biacore AB - Sweden

P08005 - Novel Lab-on-chip Technology for Label-free Detection of Posttranslational Modification Activities
Larisa Vasilets, Joerg Nerkamp, Carsten Voigt and Michael Braun,
BIOSCORA, Ltd.
Presenting Author: Larisa Vasilets, BIOSCORA - Germany

P08006 - Cambrex PKLight™ Protein Kinase Assay on the PHERAstar Plate Reader
Andrew Paine and Lee Walker,
Cambrex Bio Science
Presenting Author: Marjan Orban, BMG LABTECH GmbH - Germany

P08007 - Electrophoretic Mobility Shift as a Detection Method for Inhibitors to Protein Kinases
Jonathan Lippy, Gordon Todderud, Steve Mortillo and Litao Zhang,
Bristol-Myers Squibb Co
Presenting Author: Jonathan Lippy, Bristol-Myers Squibb Co - USA

P08008 - Development of a Receptor Tyrosine Kinase Selectivity Profiling Kit
Salvatore V. Russello, Jing Li, Jin Yuan, Christopher Bunker and Craig Thompson,
Cell Signaling Technology
Presenting Author: Kelly Gannon, Cell Signaling Technology - USA

P08009 - Validation of Serine/Threonine and Tyrosine Kinase Assays using the HTRF Technology
Salvatore V. Russello, Jin Yuan, Jing Li, Christopher Bunker, and Craig Thompson,
Cell Signaling Technology,
Josy Ouled Diaf and Emmanuel Claret,
CISbio International
Presenting Author: Salvatore Russello, Cell Signaling Technology - USA

P08010 - Non-radioactive 96-well Plate Assays for the Measurement of Kinase Activity
Jason A. Marks, Michael Batenjany, Kevin J. Harvey, Lothar Goretzki and Mo Saedi,
EMD Biosciences
Presenting Author: Jason Marks, EMD Biosciences - USA

P08011 - Multiple Ways to Address Kinase Inhibitor Selectivity
Lars Neumann, Marc-Nicola Sommer, Matthias Baumann, Sieglinde Schinzel, Birgit Flicke, Bert Klebl and Doris Hafenbradl,  
GPC Biotech AG
Presenting Author: Lars Neumann, GPC Biotech - Germany

P08012 - A Suite of Assays To Detect Phosphorylated Receptor Tyrosine Kinases Associated with Neoplasia
Timothy S. Schaefer, Jane Zhang, Sean Higgins, Laura K. Schaefer, Robert M. Umek and Jacob N. Wohlstadter,
Meso Scale Discovery
Presenting Author: Timothy Schaefer, Meso Scale Discovery - USA

P08013 - Peptide and Protein Substrates: Development of 384-well Filter Plate Based Kinase Assays
Jeffrey Busnach, Chris Barbagallo and Steven Sheridan,
Millipore Corporation
Presenting Author: Jeffrey Busnach, Millipore Corporation - USA

P08014 - Time-resolved Fluorescence Resonance Energy Transfer Detection for the IMAP™ Platform: Generic, Homogenous, TR-FRET based HTS Assays for Kinases
Annegret Boge, Francisco Ramirez, Joyce Itatani and Richard Sportsman,
Molecular Devices Inc.
Presenting Author: Annegret Boge, Molecular Devices - USA

P08015 - Evaluation of the Use of Metal Ion-phosphopeptide-binding Technologies in a Kinase Activation Cascade
Barbara Saxty, David Whalley, Keith Ansell and Debra Taylor,
MRC Technology
Presenting Author: Barbara Saxty, MRC technology - UK

P08016 - Development of High-Throughput Assay for Insulin Receptor Kinase Auto-phosphorylation
Yuichi Hirai, Takehisa Iwama and Nobutomo Tsuruzoe,
Nissan Chemical Industries, Ltd.
Presenting Author: Yuichi Hirai, Nissan Chemical Insdustries, Ltd - Japan

P08017 - Use of Flow-through Peptide Microarrays in Cell-lysate, Kinase and Inhibitor Screens
Rinie van Beuningen, Dirk D Pijnenburg, Diana D Melchers, Riet R Hilhorst, Piet P Boender, Adrienne A van de Berg and Rob R Ruijtenbeek,
PamGene International BV
Presenting Author: Rinie van Beuningen, PamGene - The Netherlands

P08018 - Homogeneous and Non-radioactive Cellular Platform for the Characterization of Kinase Inhibitors
Nathalie Rouleau, Julie Bedard, Roger Bossé and Martina Bielefeld-Sévigny,
PerkinElmer-Biosignal Inc.,
Christelle Bielmann , Fabienne Maurer, Christophe Bonny, Sylvie Guenalt, Nathalie Allaman-Pillet, Raphaël Roduit, Jacques S. Beckmann and Pascal Nicod,
University of Lausanne
Presenting Author: Martina Bielefeld-Sevigny, PerkinElmer - Canada

P08019 - Homogeneous Antibody-Free Detection of Tyrosine, Serine and Threonine Kinases Activity
Isabelle Geron,
PerkinElmer LAS Europe,
Nathalie Rouleau, Julie Bédard, Phillipe Roby, Martin Boissonneault and Roger Bossé,
PerkinElmer BioSignal Inc.
Presenting Author: Isabelle Geron, PerkinElmer LAS - Belgium

P08020 - Automated Kinase Selectivity Screening
Francis Bourbonais, Aaron Clark, Douglas Burdette, Jason Haelewyn, Erica Myron, Catherine Brzezinski, Eric Fauman, Huifen Chen, Jori Sheroski and Jeffrey Scholten,
Pfizer, Inc.
Presenting Author: Francis Bourbonais, Pfizer Inc - USA

P08021 - Human Protein Function Arrays - A Powerful New Tool in Drug Discovery and Screening
Henry Hepburne-Scott, Sarah Joyce, Mike McAndrew, Nicholas Workman, Steve Parham, Jens Koopmann, Colin Wheeler, Jonathan Blackburn and Rachel Fallon,
Procognia Ltd.
Presenting Author: Henry Hepburne-Scott, Procognia Ltd - United Kingdom

P08022 - FAC-MS Screening: Applications in Drug Discovery
Andrew Pasternak, Peter Redden, Jacek Slon-Usakiewicz, Jin-Rui Dai, William Ng, Estelle Foster, Eugen Deretey and Lee Shekter,
Protana Inc.
Presenting Author: Andrew Pasternak, Protana Inc. - Canada

P08023 - A Far Red Fluorescence QTL Lightspeed® 'Snap on' Assay for Detection of Kinase Activity using Biotinylated Peptides
Frauke Rininsland, Shannon Wittenburg and Casey Stankewicz,
QTL Biosystems
Presenting Author: Frauke Rininsland, QTL Biosystems - USA

P08024 - High Throughput Homogeneous Cell-Based Assays of Receptor Signaling Pathways: A Discovery Platform for Kinase Drug Discovery
Michael F. Crouch, Ron I.W. Osmond, and Anthony R. Dyer,
TGR BioSciences
Presenting Author: Michael Crouch, TGR BioSciences - Australia

P08025 - Screening Lipid Kinases: a Comparison of Luminescence and Microfluidic Chip Assay Formats
Todd Rowe, Trace Tsuruda, and John D. McCarter,
Amgen , Inc.,
Holly Reardon, Amy Wang, and Javier Farinas,
Caliper Life Sciences
Presenting Author: Javier Farinas, Caliper Life Sciences - USA

P08026 - A Cell-Based High-Throughput Screen Assay for Positive Modulators of Insulin Receptor
Augustin Amour, Stuart Baddeley, Joyce Boucheron, Liz Clark, Tony Fox and Steve Ludbrook,
GlaxoSmithKline
Presenting Author: Augustin Amour, GlaxoSmithKline - United-Kingdom

P08027 - Identification of Inhibitors of the Kinase Activity of Oncogenic V600EBRAF in an Enzyme Cascade High Throughput Screen
Yvette Newbatt, Samantha Burns, Robert Hayward, Steven Whittaker, Ruth Kirk, Christopher Marshall, Caroline Springer, Edward McDonald, Cancer Genome Project (The Wellcome Trust Sanger Institute), Richard Marais, Paul Workman and Wynne Aherne,
The Institute of Cancer Research
Presenting Author: Yvette Newbatt, Institute of Cancer Research - UK

P08028 - Homogeneous and Non-radioactive HTS Platform for the Characterization of Kinase Inhibitors in Cells Lysates
Raphaël Roduit, Sylvie Guenat, Christelle Bielmann, Fabienne Maurer, Nathalie Allaman-Pillet, Pascal Nicod, Jacques S. Beckmann and Christophe Bonny,
CHUV,
Nathalie Rouleau, Julie Bedard and Roger Bossé,
PerkinElmer Biosignal Inc.
Presenting Author: Raphael Roduit, CHUV - Switzerland

P08029 - Bead Based Array for Phospho-protein Detection: Adaptation of the CBA Kit to Screening
Caroline Waltzinger, Isabelle Martinou, Alexander Scheer and Paul Lang,
SERONO SPRI
Presenting Author: Caroline Waltzinger, SERONO SPRI - SWITZERLAND

P08030 - KinEASE HTRF: New Tools for Rapid Kinase Assay Development
Emmanuel J. Claret, Cedric Leroy, Josy Ouled-Diaf, Cathy Drexler, Patrick Seguin and David J. Hayes (Upstate),
Cisbio international
Presenting Author: Emmanuel Claret, Cisbio international - France

P08031 - Cell Based Assays to Find Inhibitors of Cells with a Specific Phenotype
Mark Stubbs, Lisa Pickard and Wynne Aherne,
Institute of Cancer Research.
Presenting Author: Mark Stubbs, Institute of Cancer Research - UK

P08032 - Functional Pharmacology: Characterization of Kinase Inhibitors within a Dynamic Cellular Environment
Lisa Martel, Sidney Bounds, Kirk Rorrer, Karen Yoshino and Jamie Baumgartner,
MDS Pharma Services
Presenting Author: Lisa Martel, MDS Pharma Services - USA

P08033 - A High Content Primary Screening Assay Identifying Multiple Protein Targets in a Cell Using Quantum Dots.
Marcel Bruchez, Christopher Lupton (TTP Labtech, Inc.), Dick Ornberg and Paul Wylie (TTP Labtech, Inc.),
Quantum Dot Corporation
Presenting Author: Marcel Bruchez, Quantum Dot Corporation - USA

P08034 - Development of a Luciferase-coupled Kinase Assay to Facilitate Screening of Enzymes that Demand High ATP Concentrations: Application to HTS and Medicinal Chemistry Support Screening for Tight Binding Inhibitors
James Westcott, Paul Wang, Adam Tanner, Gemma Braidley, Neesha Dedi, John Pollard,
Vertex Pharmaceuticals (Europe) Ltd.
Presenting Author: James Westcott, Vertex Pharmaceuticals (Europe) Ltd - UK

P08035 - IMAP Assay for Evaluating PKC Isoforms
Xiaoke Yang, Julie Lee, Paul Morgan, Lori Fitz, Fred Immermann, Divya Chaudhary and Stan Wolf,
Wyeth Research
Presenting Author: Xiaoke Yang, Wyeth Research - USA

P08036 - Identification of Kinases Affecting Downstream Phenotypic Changes in Cell Morphology and Cytoskeleton by the High Content Screening Evaluation of a siRNA Library
Richik N. Ghosh, Michael A. Sipe, Linnette E. Grove, Rich Jarvis (Ambion, Inc.), Mike Byrom (Ambion, Inc.), David Brown (Ambion, Inc.), and Jeffrey R. Haskins,
Cellomics, Inc.
Presenting Author: Jeffrey Haskins, Cellomics, Inc. - USA

P08037 - A Novel Kinase Assay Technology Applicable to Target Validation, Assay Development and Primary and Secondary Screening
K.R. Olson, L. Kauffman, R. Singh, N. Charter, V. Shenoy and R.M. Eglen,
DiscoveRx Corporation
Presenting Author: Keith Olson, DiscoveRx - USA

P08038 - ADP Hunter™ A Generic Homogeneous Assay for HTS Kinase Inhibitor Screening
K. Olson, L. Kauffman, V. Shenoy and R. Eglen,
DiscoveRx Corporation
Presenting Author: Keith Olson, DiscoveRx - USA

P08039 - A Peptide-based Microfluidic Mobility Shift Assay from Protein Phosphatases Targets
Seth Cohen, Laurel Provencher and Abbie Esterman,
Caliper Life Sciences
Presenting Author: Seth Cohen, Caliper Life Sciences - USA

P09001 - A Data Management System for Screening of Natural Products
Antonio Danese, Dario Bastianello, Lorenzo Uda (Vicuron Pharmaceuticals) and Daniele Losi (Vicuron Pharmaceuticals),
DV Informatica Srl
Presenting Author: Antonio Danese, DV Informatica Srl - ITALY

P09002 - A Search and Visualization Integrated Tool for HTS and Lead Optimization
Elisabetta Vannini, Leopoldo Allievi (Inpharzam Ricerche SA), Dario Bastianello, Franco Pellacini (Inpharzam Ricerche SA), Carlo Scandalitta and Raimondo Fattori (Inpharzam Ricerche SA),
DV Informatica Srl
Presenting Author: Elisabetta Vannini, DV Informatica Srl - ITALY

P09003 - Fluorescent Artifacts in HTS
Dirk Ullmann, Nicolas Fay, Kaupo Palo (Evotec Technologies GmbH), Dirk Winkler, Joachim Kraemer, Thomas Hesterkamp and Julian Woelcke,
Evotec AG
Presenting Author: Dirk Ullmann, Evotec AG - Germany

P09004 - Multiplicity: The Challenge of Analyzing High-Content Screening Data
Damian Verdnik,
Molecular Devices Corporation
Presenting Author: Damian Verdnik, Molecular Devices Corporation - Australia

P09005 - Merging Advanced Screening Technologies to Support HTS in Delivering with Better Hits
Christèle Frémaux, Daniel Dominé, Alexander Scheer and Dominique Besson,
Serono Pharmaceutical Research Institute.
Presenting Author: Christèle Frémaux, Serono - Switzerland

P10001 - A High Throughput Platform for Cell Clonality: Impact on Hybridoma Technology
Steven C.Miller, Paul B. Comita, Chris Shumate and Evan F. Cromwell,
Blueshift Biotechnologies, Inc.
Presenting Author: Steven C. Miller, Blueshift Biotechnologies, Inc. - USA

P10002 - High-Throughput Measurement of Protein Stability using the FLUOstar
Jean P. Aucamp, Ana M. Cosme, Gary J. Lye and Paul A. Dalby,
University College London
Presenting Author: Marjan Orban, BMG LABTECH GmbH - Germany

P10003 - Cambrex Bio Science MycoAlert™ Assay on the LUMIstar Plate Reader
Anne Cox and Anthony Pitt,
Cambrex Bio Science
Presenting Author: Marjan Orban, BMG LABTECH GmbH - Germany

P10004 - Intraceptor Interference of VEGF Pathways
Balamurali K. Ambati, Nirbhai Singh, Tushar Suthar, Pooja Jani, Devander Dhanda and Uday Kompella,
Medical College of Georgia
Presenting Author: Bala Ambati, Medical College of Georgia - USA

P10005 - Solubilization and Stabilization of Membrane Proteins for Drug Discovery Assay Development
Vladimir Trubetskoy, Thomas Burke, Kerry Ervin, Olga Trubetskoy and Moshe Finel (University of Helsinki),
Quintessence Biosciences
Presenting Author: Vladimir Trubetskoy, Quintessence Biosciences - usa

P10006 - Study of Peripheral Venouse Catheter-related Bacteria Infections (PVC) and their Role in Establishing Septicemia and Their Antimicrobial Resistance
Amir Ghasemi , Mohamad Hasan Shirazi and Mojdeh Farhang Nejad,
University of Medical Sciences of Tehran
Presenting Author: Amir Ghasemi, University of medical sciences of Tehran - Iran

P10007 - Study of Helicobacter Pylori Prevalence in Patients with Gastrointestinal Lesions Referred to Tehran Hospitals (2003-2004)
Mohamad Hasan Shirazi, Amir Ghasemi, and Mohammad Reaza Hagh,
University of Medical Sciences of Tehran
Presenting Author: Mohammad Hasan Shirazi, University of medical sciences of Tehran - Iran

P10008 - Cryopreserved Cells - A New, More Efficient and Economical Way to Use Cells in Screening
Louise Stjernborg and Nan Albertson,
AstraZeneca
Presenting Author: Louise Stjernborg, AstraZeneca R&D Mölndal - Sweden

P11001 - Alzheimer's Disease the Future Impact on Family and Health Care Cost.
Michelina Eva Weicker,
Alvernia College
Presenting Author: Michelina Eva Weicker, Alvernia College - U.S.A

P11002 - Triacylglycerol Lipases and ACAT2: HTS Assay Configuration on Key Cardiovascular Targets
S. Lohmer, L. Redaelli, B. Bellanti, P. Arioli, D. Carettoni,
Axxam srl
Presenting Author: Stefan Lohmer, Axxam - Italy

P11003 - Preparation and Drug Release Study of Oral Colon Targeted Delivery System for Metronidazole
Naser Tavakoli, Jaleh Varshosaz and Ayatollah Ilani,
Isfahan University of Medical Sciences
Presenting Author: Naser Tavakoli, Isfahan University of Medical Sciences - IRAN

P11004 - Ultrafiltration for Biomarker Sample Preparation
Aldo M. Pitt, Sara Gutierrez, and Elena Chernokalskaya,
Millipore Corporation
Presenting Author: Aldo Pitt, Millipore Corporation - USA

P11005 - An E. coli Transcription and Translation Screen Uncovers Two Novel Antibacterial Series Targeting RNA Polymerase
Michael Dermyer, Michael Kuhn, Steve Dunham, Paul Pagano, William Dunkle, Scott Wise, Ramy Shammas, Robert Landick (University of Wisconsin-Madison), and Tod Holler,
Pfizer Global Research and Development
Presenting Author: Michael Dermyer, Pfizer - US

P11006 - Automatic Vacuum Filtration System for Filter Plate Applications
Sunghou Lee,
Sangmyung University
Presenting Author: Sunghou Lee, Sangmyung University - Republic of Korea

P11007 - An Evaluation of the Potent Inhibitory Effects of Royal Jelly Fractions Against Streptomyces Bacteria
Saeed Eshraghi,
Tehran University of Medical Sciences
Presenting Author: Saeed Eshraghi, School of Public Health - I.R.IRAN

P11008 - Evaluation of Two ELISA Methods for Diagnosis of Acute Leptospirosis
Hamidreza Honarmand, Saeed Eshraghi, Mohammad R.Khoramizadeh, Rudy A.Hartskeerl and Fariborz M. Ghanaei ,
Tehran Univ.Med.Sciences
Presenting Author: Hamidreza Honarmand, School of Public Health, Tehran Univ.Med.Sciences - IR. IRAN

P11009 - Magnetic Particles for Extracting Nucleic Acids from Whole Blood Without Lysis
Hashem Akhavan-Tafti, Renuka deSilva, Monica A. Bray, William G. Cripps, Robert A. Eickholt, Richard S. Handley, Kenneth S. Lauwers, Mark D. Sandison, Sarada Siripurapu, A. Paul Schaap and Wenhua Xie,
Lumigen Inc.
Presenting Author: Hashem Akhavan-Tafti, Lumigen Inc. - USA

P12001 - In Vitro Antobacterial Activities of Enololone on Isolated Streptococcus mutans Species as the Main Important Bacteria in Producing Human Dental Caries
Mohammad Hossein Salari, Abbas Mirshafiey, Robaba Hafezi, Ali Reza Khoshkholgh,
Tehran University of Medical Sciences
Presenting Author: Mohammad Hossein Salari, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences - Iran

P12002 - Comparison Between Different Methodologies for Assessing and Improving Volume Delivery from ALH Equipment
John Thomas Bradshaw, Tanya Knaide, Ceara McNally, Alex Rogers and Richard Curtis,
Artel, Inc.
Presenting Author: John Bradshaw, Artel, Inc. - United States

P12003 - Whatever Happened to Fluorescence Lifetime Screening? - New Developments That Solve Old Problems
Pierre Graves, Mike O'Sullivan, J Anthony Smith and John Whateley,
AssayMetrics Limited
Presenting Author: Pierre Graves, AssayMetrics Limited - UNITED KINGDOM

P12004 - Rapid Kinetic Screening and High-resolution Kinetic Characterization of Antibodies using a Protein Interaction Array System
Robert Karlsson, Pär Säfsten, Scott L. Klakamp (Abgenix Inc)