| An Automated LC/MS/MS Protocol To Enhance Throughput Of Physico-Chemical Property Profiling In Drug Discovery |
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Presentation: P03034 Session: Robotic Screening & Automation Technologies - Poster SessionDarcy Shave, Peter G. Alden, Kate Yu, Rob Plumb and Warren Potts, Waters Corp. Presenting Author: Darcy Shave, Waters Corporation - USA Early screening of physicochemical properties (PP) is an integral process for modern drug discovery. Typical PP profiling practice includes properties such as solubility, stability (pH and metabolic), permeability, integrity, etc. The critical factor to consider in PP profiling is throughput. The bottlenecks to throughput include MS method optimization for a large variety of compounds and data management for the large volume of data generated. We have developed an automated LC/MS/MS protocol that not only allows for automated MS method development and data acquisition, but also allows data generated from multiple tests to be processed by a single processing method, all in an automated fashion. As a result, the physico-chemical profiling process was significantly simplified and throughput increased. |