| An Ultra-High Throughput Approach to High Content Screening in 1536-Well Format |
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Presentation: P03031 Session: Robotic Screening & Automation Technologies - Poster SessionYan Wang, Robert Davis (Kalypsys, Inc.) and Wayne Bowen, TTP LabTech Ltd Presenting Author: Wayne Bowen, TTP LabTech Limited - UK Kalypsys’ technology has enabled unprecedented levels of efficiency and economy in primary screening, and has proved especially useful at rapidly profiling screening hits in selectivity and safety assays. Combining throughput of over 1 million assay wells per day with on-line storage capacity of over 2 million compounds, the Kalypsys System provides unmatched screening efficiency. To effectively utilize whole cell assay formats in primary and secondary screening, image-based high content readers require multi-channel capability, rapid read times and compatibility with high-density plate formats. The Acumen Explorer offers whole-well, high content analysis of 1536 microplates in less than 10 minutes per plate, while collecting data for up to four colors in multiplex protocols, thus combining the object-recognition capabilities of image-based systems with short read times. Here, we demonstrate the powerful integration of an Acumen Explorer with Kalypsys technology, with capability to screen > 300,000 wells per day of high content data. |