| Library Maintenance for the Smaller Pharma |
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Presentation: P01009 Session: Cheminformatics, Library Design and Virtual HTS - Poster SessionSally Hampton, Doreen Ashworth, Peter Robson, Chris Yea and James Barnett, Ferring Research Ltd. Presenting Author: Sally Hampton, Ferring Research Ltd - UK There have been many discussions regarding the problems encountered when storing compounds in DMSO solution, in particular DMSO hydration and compound precipitation. Smaller pharmaceutical companies do not have at their disposal the dedicated compound handling facilities of the larger companies. Bulk purchase of a new library gave us the opportunity to explore new processes for storing and maintaining library compounds. Our main considerations were compound integrity, limited storage space and readily available equipment. We discuss a dry film solution that has solved both the compound integrity and physical storage issues using standard liquid and compound handling techniques. The result is that we have assay ready boxed sets of screening plates for HTS. |