Brigham and Women's Hospital and Havard Medical School
Laboratory for Drug Discovery in Neurodegeneration (LDDN) and the National Center for Drug Discovery in Neurodegeneration (NCDDN) and Partners Center for Drug Discovery (PCDD)
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Marcie Glicksman, Sr. Director of Leads Discovery |
| Email Address: |
mglicksman@rics.bwh.harvard.edu |
| Types of Libraries Screened: |
Small Molecule,Other (please specify below)
purified natural products and tetrapeptides as well |
| Small Molecule Library Size: |
101-150K |
| Detection Tecnologies Used: |
Multi-mode plate reader,Imaging plate reader (e.g. FLIPR),High throughput scintillation counter
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
We welcome collaborations. Our focus is on drug discovery and with our medicinal chemistry group, our goal is to develop molecules that show efficacy in a relevant disease model. We look for partners for our programs with the pharmaceutical, biotech, and associated industry. |
|
Broad Institute Chemical Biology Platform
Broad Institute Chemical Biology Platform
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Nicola Tolliday, Head of Screening |
| Email Address: |
tolliday@broad.harvard.edu |
| Types of Libraries Screened: |
Small Molecule
|
| Small Molecule Library Size: |
101-150K |
| Detection Tecnologies Used: |
screening microscope
|
| Is the Facility's Screening Data Public? |
Yes |
| Public Data Access URL: |
http://chembank.broad.harvard.edu/ |
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
The Broad Institute's screening facility is home to the National Cancer Institute's Initiative for Chemical Genetics (ICG). The ICG hosts a highly successful Investigator-Initiated Screening Program that has facilitated small molecule screening projects for more than 145 different research groups from throughout the U.S. and abroad. The program assists academic researchers in carrying out high-throughput screens of chemical libraries to identify new tools for biological research, with a particular emphasis on cancer biology and therapeutics. |
|
Broad Institute of Harvard and MIT
Broad Institute Imaging Platform
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Dr. Anne Carpenter, Director |
| Email Address: |
anne@broadinstitute.org |
| Types of Libraries Screened: |
Other (please specify below)
no sample preparation or image acquisition at the facility, image processing and data mining only |
| Small Molecule Library Size: |
|
| Detection Tecnologies Used: |
Our research group is entirely computational (image processing and data mining) so we do not carry out sample preparation or image acquisition |
| Is the Facility's Screening Data Public? |
Yes |
| Public Data Access URL: |
to be announced |
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
The Broad Institute's Imaging Platform uses advanced methods to quantify and mine the rich information present in cellular images from high content screens to yield biological discoveries. We develop open-source software tools for cell image analysis (CellProfiler) and HCS data exploration (CellProfiler Analyst)
(www.cellprofiler.org) and help biologists to apply them to significant questions in the life sciences. The research group is happy to collaborate with groups who are acquiring images from large-scale screens but are unable to score phenotypes using conventional software. We also welcome visitors to visit and train with us so as to implement similar open-source solutions back at their home institutions. Note that the Imaging Platform extracts information from cell images; it does not prepare or image cell samples. See the Broad Institute's Chemical Biology Platform and RNAi Platform for these types of collaborations.
|
|
Burnham Institute for Medical Research
San Diego Center for Chemical Genomics
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Dr. Nicholas D.P. Cosford, Project Manager |
| Email Address: |
ncosford@burnham.org |
| Types of Libraries Screened: |
Small Molecule,RNAi
|
| Small Molecule Library Size: |
|
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope
|
| Is the Facility's Screening Data Public? |
Yes |
| Public Data Access URL: |
http://pubchem.ncbi.nlm.nih.gov/ |
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
|
|
Cancer Research UK
Cancer Research Technology Discovery Laboratories
| Located in: |
United Kingdom |
| Website: |
Click here to go to their website |
| Primary Contact: |
Tim Hammonds, |
| Email Address: |
|
| Types of Libraries Screened: |
Small Molecule
|
| Small Molecule Library Size: |
51-100K |
| Detection Tecnologies Used: |
Multi-mode plate reader
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
At CRT we perform HTS/drug discovery on targets arising from academic or publicly funded cancer research, with the goal of taking them to a stage of in vivo potency. CRT is wholly owned by a charity and is as such a non-profit cancer drug discovery company Targets are accepted on the basis of a number of strict criteria concerning their applicability to cancer therapy. |
|
CEA, Life Sciences Division - Institute of biology technologies - Saclay (IBITEC-S)
Combinatorial chemistry and high-throughput screening platform
| Located in: |
France |
| Website: |
Click here to go to their website |
| Primary Contact: |
Roman Lopez, Platform technical head |
| Email Address: |
roman.lopez@cea.fr |
| Types of Libraries Screened: |
Small Molecule
|
| Small Molecule Library Size: |
11-50K |
| Detection Tecnologies Used: |
Multi-mode plate reader,High throughput scintillation counter
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
Combining chemistry and biology, the aim of the platform is to speed-up bio-active compounds discovery process in order to obtain new chemical tools for biology or identifying new targets or potential drugs families. iBITEC-S (dir. by Pierre Legrain) integrates mixed teams of fundamental research and mission-oriented research led alongside the pharmaceutical industry, agribusiness, or the biotech sector with the aim of develop world-class R&D projects partnerships with industries. |
|
Center for Cancer Research, National Cancer Institute
Molecular Targets Development Program
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
James McMahon, Director |
| Email Address: |
mcmahon@ncifcrf.gov |
| Types of Libraries Screened: |
Small Molecule,Other (please specify below)
natural product extracts |
| Small Molecule Library Size: |
101-150K |
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
No |
| Additional Comments |
MTDP primarily serves the Intramural Program of the NCI.
|
|
Central Drug Research Institute, India
High Throughput/High Content Screening Facility
| Located in: |
India |
| Website: |
Click here to go to their website |
| Primary Contact: |
Anil Gaikwad, Scientist, HTS Facility |
| Email Address: |
anil_gaikwad@cdri.res.in |
| Types of Libraries Screened: |
Small Molecule,RNAi,Other (please specify below)
Natural Product Extracts |
| Small Molecule Library Size: |
|
| Detection Tecnologies Used: |
Multi-mode plate reader,Imaging plate reader (e.g. FLIPR),Screening microscope,High throughput flow cytometry,High throughput scintillation counter
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
We are more open to collaborative projects rather than service projects. We have experties in infectious diseases as well as metabolic diseases. Assay development and screening, further follow up projects (ADMET, Mode of action) can be taken. |
|
Children's Cancer Institute Australia for Medical Research
ACRF Drug Discovery Centre for Childhood Cancer
| Located in: |
Australia |
| Website: |
Click here to go to their website |
| Primary Contact: |
Dr. Dr Greg Arndt, Drug Discovery Manager |
| Email Address: |
garndt@ccia.org.au |
| Types of Libraries Screened: |
Small Molecule
|
| Small Molecule Library Size: |
151-300K |
| Detection Tecnologies Used: |
Other (please specify below)
Label-free system |
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
|
|
CNRS and University Strasbourg I (Universite Louis pasteur)
PCBIS Plateforme de Chimie Biologie Integrative de Strasbourg (Screening Strasbourg Platform)
| Located in: |
France |
| Website: |
Click here to go to their website |
| Primary Contact: |
Jacques HAIEC, Scientific director |
| Email Address: |
haiech@pharma.u-strasbg.fr |
| Types of Libraries Screened: |
Small Molecule
|
| Small Molecule Library Size: |
11-50K |
| Detection Tecnologies Used: |
Multi-mode plate reader,High throughput flow cytometry,High throughput scintillation counter,Other (please specify below)
Microfluidic facilities |
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
The platform is certified ISO9001. The platform is specialized in biophysical tests using FRET and fluorescence anistropy to assay ligand-protein interactions.
|
|
Commissariat & l'Energie atomique, departement des Sciences du Vivant (CEA/DSV) CNRS
Center for Bio-Active Molecules Screening (Centre de Criblage pour Molecules Bio-Actives (CMBA))
| Located in: |
France |
| Website: |
Click here to go to their website |
| Primary Contact: |
Laurence Lafanechre, Scientific director of CMBA |
| Email Address: |
laurence.lafanechere@cea.fr |
| Types of Libraries Screened: |
Small Molecule
|
| Small Molecule Library Size: |
11-50K |
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
We are experienced in cell-based assays and are greatly interested in direct chemical genetics approaches. Our main area of interest is cancer and cytoskeleton. Our facility is opened to other intitutions after agreement of the platform's scientific committee and contractualisation of the collaboration. |
|
Duke Center for RNA Biology Duke Institute for Genome Sciences and Policy Duke Comprehensive Cancer Center
Duke RNAi Facility
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
James Pearson, Manager |
| Email Address: |
pears016@mc.duke.edu |
| Types of Libraries Screened: |
Other (please specify below)
Open Biosystems Human shRNA library |
| Small Molecule Library Size: |
|
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope,Other (please specify below)
Cellomics Arrayscan Vti |
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
No |
| Additional Comments |
|
|
Emory University
Emory Chemical Biology Discovery Center
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Haian Fu, Professor and Director |
| Email Address: |
hfu@emory.edu |
| Types of Libraries Screened: |
Small Molecule,RNAi
|
| Small Molecule Library Size: |
101-150K |
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope,Other (please specify below)
FlexStation |
| Is the Facility's Screening Data Public? |
Yes |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
Emory Chemical Biology Discovery Center is part of the NIH Molecular Libraries Screening Centers Network (MLSCN; http://www.mli.nih.gov/). Following individuals can be reached for molecular probe development related issues. Dr. Ray Dingledine (Principal Investigator of the Emory Center in MLSCN; Email: rdingledine@pharm.emory.edu) Dr. Dennis Liotta (Medicinal Chemistry operation) Dr. James P. Snyder (ChemInformatics operation) |
|
EPFL, Ecole Polytechnique Fédérale de Lausanne
Biomolecular Screening Facility
| Located in: |
Switzerland |
| Website: |
Click here to go to their website |
| Primary Contact: |
Dr. Gerardo Turcatti, |
| Email Address: |
gerardo.turcatti@epfl.ch |
| Types of Libraries Screened: |
Small Molecule,RNAi,Other (please specify below)
Natural products extracts |
| Small Molecule Library Size: |
11-50K |
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope,High throughput flow cytometry
|
| Is the Facility's Screening Data Public? |
Yes |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
Misison statement: The Biomolecular Screening Facility (BSF) at the EPFL School of Life Sciences (Faculté des sciences de la vie, FSV) is a multidisciplinary laboratory created for performing high throughput screening in life sciences-related projects. The BSF holds the necessary infrastructure, multidisciplinary expertise and flexibility for screening a variety of compound libraries including RNA molecules and chemicals in both cellular and biochemical target-based assay. The main mission of this versatile platform is to be active in the fields of Functional Genomics and Chemical Biology for contributing to the discovery of biologically-relevant molecular probes and new diagnostic and therapeutic avenues. |
|
Fox Chase Cancer Center
Translational Research Facility
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Margaret Einarson, Manager |
| Email Address: |
margret.einarson@fccc.edu |
| Types of Libraries Screened: |
Small Molecule,RNAi
|
| Small Molecule Library Size: |
11-50K |
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope,High throughput flow cytometry
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
We are a recently formed screening facility
|
|
German Federal Ministry of Education and Research (Bmbf)
European ScreeningPort
| Located in: |
Germany |
| Website: |
Click here to go to their website |
| Primary Contact: |
Mira Graettinger, |
| Email Address: |
contact@screeningport.com |
| Types of Libraries Screened: |
Small Molecule
|
| Small Molecule Library Size: |
151-300K |
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope,Other (please specify below)
PE Opera (HCS), FliPR Reader |
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
Any additional comments or information that would be helpful:
The goal of the European Screeningport is to transform the exciting new science, taking place at the benchtops of Europe’s academic laboratories, into chemical tools and high quality assets.
We provide:
• deep scientific insight and established links with world class research institutions
• wide ranging industry experience across target classes and therapeutic areas
• access to high quality compound libraries and state of the art screening facilities
• Pharma scale medicinal chemistry and bioinformatics infrastructure and processes, without the need for capital investments
• a pragmatic approach to intellectual property that encourages innovation and reinforces collaborative working.
• co-ordination of SAR seeking and medicinal chemistry programs by leveraging the world-class facilities of its partners
|
|
Griffith University
Eskitis Molecular Screening - Queensland Compound Library
| Located in: |
Australia |
| Website: |
Click here to go to their website |
| Primary Contact: |
Dr. David Camp, Director |
| Email Address: |
|
| Types of Libraries Screened: |
Small Molecule,Other (please specify below)
Pre-fractionated natural product extracts |
| Small Molecule Library Size: |
|
| Detection Tecnologies Used: |
Multi-mode plate reader,Imaging plate reader (e.g. FLIPR)
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
Eskitis Molecular Screening comprises the Queensland Compound Library and the Queensland Screening Centre
|
|
Harvard Medical School
ICCB-Longwood Screening Facility
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Caroline Shamu, Director |
| Email Address: |
caroline_shamu@hms.harvard.edu |
| Types of Libraries Screened: |
Small Molecule,RNAi
|
| Small Molecule Library Size: |
|
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
ICCB-L shares space and personnel with the NSRB Screening Facility. The NSRB focuses on projects related to biodefense and emerging infectious disease.
|
|
Harvard Medical School Department of Genetics
Drosophila RNAi Screening Center (DRSC)
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Bernard Mathey-Prevot, DRSC, Director |
| Email Address: |
bprevot@receptor.med.harvard.edu |
| Types of Libraries Screened: |
RNAi
|
| Small Molecule Library Size: |
11-50K |
| Detection Tecnologies Used: |
Multi-mode plate reader,Screening microscope
|
| Is the Facility's Screening Data Public? |
Yes |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
Yes |
| Additional Comments |
to send an application to do screens at the DRSC, go to: http://flyrnai.org/app_policy.html
|
|
Indiana University School of Medicine
Chemical Genomics Core Facility
| Located in: |
United States |
| Website: |
Click here to go to their website |
| Primary Contact: |
Lan Chen, Director of HTS |
| Email Address: |
lanchen@iupui.edu |
| Types of Libraries Screened: |
Small Molecule
|
| Small Molecule Library Size: |
51-100K |
| Detection Tecnologies Used: |
Multi-mode plate reader
|
| Is the Facility's Screening Data Public? |
No |
| Public Data Access URL: |
|
| Does the Facility Perform Screening for Non-Affiliated Organizations? |
No |
| Additional Comments |
|
|
|
